Reactome: A Curated Pathway Database

InlB binds MET

Stable Identifier
R-HSA-8875371
Type
Reaction
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Locations in the PathwayBrowser
Summation

InlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist. InlB interacts with the extracellular portion of MET via two interfaces: the leucine rich repeat region (LRR) of InlB interacts with the Ig1 repeat of MET, while the inter-repeat (IR) region of InlB interacts with the Sema domain of MET (Shen et al. 2000, Veiga and Cossart 2005, Niemann et al. 2007).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis