Reactome | MET binds TNS3

MET binds TNS3

Stable Identifier

R-HSA-8875523

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Activated MET receptor binds to tensin-3 (TNS3). The functional role of this interaction is not known. TNS3 is downregulated in colorectal, lung, ovarian and gastric cancers that show upregulation of tensin-4 (TNS4) (Muharram et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24814316	Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells Sahgal, P, Kaukonen, R, Muharram, G, Carpén, O, Korpela, T, De Franceschi, N, Ivaska, J, Clark, K, Tulasne, D	Dev. Cell	2014