Reactome | MET binds TNS4

MET binds TNS4

Stable Identifier

R-HSA-8875531

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated MET receptor binds the complex of tensin-4 (TNS4) and integrin beta-1 (ITGB1). This interaction involves arginine residue R474 at the SH2 domain of TNS4 and phosphorylated tyrosines Y1349 and Y1356 of MET. Phosphorylated Y1313 of MET contributes to TNS4 binding but the kinase responsible for phosphorylation of MET at Y1313 is not known. TNS4, ITGB1 and MET co-localize at paxillin-positive focal adhesion sites. Binding of MET to TNS4 contributes to cell motility and promotes activation of AKT, but not ERK, downstream of MET. TNS4 is upregulated in colorectal, lung, ovarian and gastric cancer, with concomitant downregulation of TNS3. TNS4 and MET expression correlate in colorectal and ovarian cancer (Muharram et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24814316	Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells Sahgal, P, Kaukonen, R, Muharram, G, Carpén, O, Korpela, T, De Franceschi, N, Ivaska, J, Clark, K, Tulasne, D	Dev. Cell	2014