GAB1 recruits CRK,CRKL to MET

Stable Identifier
R-HSA-8875540
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Splicing isoforms of adapter protein CRK, CRK-1 (CRKI) and CRK-2 (CRKII), as well as the related adapter protein CRKL can be recruited to the activated MET receptor via association with tyrosine phosphorylated GAB1 (Garcia-Guzman et al. 1999, Schaeper et al. 2000, Sakkab et al. 2000, Lamorte et al. 2000, Lamorte et al. 2002).

Literature References
PubMed ID Title Journal Year
10618718 Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

Garcia-Guzman, M, Dolfi, F, Zeh, K, Vuori, K

Oncogene 1999
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
11146548 A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

Lamorte, L, Kamikura, DM, Park, M

Oncogene 2000
12138161 Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program

Lamorte, L, Rodrigues, S, Naujokas, M, Park, M

J. Biol. Chem. 2002
10753869 Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

Sakkab, D, Lewitzky, M, Posern, G, Schaeper, U, Sachs, M, Birchmeier, W, Feller, SM

J. Biol. Chem. 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed