MET receptor recycling

Stable Identifier
R-HSA-8875656
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Pathway
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Homo sapiens
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Activated MET receptor is subject to recycling from the plasma membrane through the endosomal compartment and back to the plasma membrane (Peschard et al. 2001, Hammond et al. 2001, Petrelli et al. 2002). In the recycling process, activated MET receptor is endocytosed, and the GGA3 protein directs it, via a largely unknown mechanism, through the RAB4 positive endosomal compartments back to the plasma membrane (Parachoniak et al. 2011). Endosomal signaling by MET during the recycling process appears to play an important role in sustained activation of ERK1/ERK2 (MAPK3/MAPK1) and STAT3 downstream of MET (Kermorgant and Parker 2008).

Literature References
PubMed ID Title Journal Year
11894096 The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

Petrelli, A, Gilestro, GF, Lanzardo, S, Comoglio, PM, Migone, N, Giordano, S

Nature 2002
18779368 Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation

Kermorgant, S, Parker, PJ

J. Cell Biol. 2008
11420688 Down-regulation of MET, the receptor for hepatocyte growth factor

Hammond, DE, Urbé, S, Vande Woude, GF, Clague, MJ

Oncogene 2001
21664574 GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration

Parachoniak, CA, Luo, Y, Abella, JV, Keen, JH, Park, M

Dev. Cell 2011
11741535 Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

Peschard, P, Fournier, TM, Lamorte, L, Naujokas, MA, Band, H, Langdon, WY, Park, M

Mol. Cell 2001
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