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GGC-RAB10 [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-8876076
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
Ras-related protein Rab-10, RAB10_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
DENND4s exchange GTP for GDP on RAB10 (Homo sapiens)
GGC-RAB10:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10 [cytoplasmic vesicle membrane] (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)
GGC-RAB8A,10,13,14:GDP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10:GDP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10 [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB8A,10,13,14:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10 [cytoplasmic vesicle membrane] (Homo sapiens)
RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)
GGC-RAB8A,10,13,14 [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10 [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB8A,10,13,14:GDP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10:GDP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10 [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB8A,10,13,14:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10 [cytoplasmic vesicle membrane] (Homo sapiens)
SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)
GGC-RAB8A,10,13,14:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10 [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61026 RAB10
Gene Names
RAB10
Chain
chain:1-200
Reference Genes
BioGPS Gene:10890 RAB10
COSMIC (genes):RAB10 RAB10
CTD Gene:10890 RAB10
dbSNP Gene:10890 RAB10
ENSEMBL:ENSG00000084733 RAB10
ENSEMBL_homo_sapiens_GENE:ENSG00000084733.11 RAB10
HGNC:9759 RAB10
KEGG Gene (Homo sapiens):10890 RAB10
Monarch:10890 RAB10
NCBI Gene:10890 RAB10
OMIM:612672 RAB10
UCSC:P61026 RAB10
Reference Transcript
RefSeq:NM_016131.4 RAB10
Other Identifiers
10890
11742995_at
11758142_s_at
16877836
222980_PM_at
222980_at
222981_PM_s_at
222981_s_at
2473572
2473573
2473574
2473575
2473597
2473602
2473603
2473613
2473616
2473620
2473621
2473622
2473623
2473624
2473625
2473626
2473627
2473628
49068_at
52273_s_at
8040618
A_14_P120786
A_14_P126393
A_23_P165879
A_24_P319675
GE61456
GO:0000139
GO:0000145
GO:0000166
GO:0002376
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0005929
GO:0006893
GO:0007155
GO:0007163
GO:0007409
GO:0008092
GO:0010008
GO:0015031
GO:0016020
GO:0016192
GO:0016197
GO:0016787
GO:0019003
GO:0019882
GO:0030154
GO:0030659
GO:0030667
GO:0030670
GO:0030859
GO:0031410
GO:0031489
GO:0032593
GO:0032869
GO:0042995
GO:0043001
GO:0043226
GO:0045055
GO:0045200
GO:0048471
GO:0048856
GO:0051668
GO:0055037
GO:0055038
GO:0070062
GO:0070382
GO:0071782
GO:0071786
GO:0072659
GO:0090150
GO:0097051
GO:0098609
GO:0098631
GO:0098641
GO:0098772
GO:0120025
GO:1903361
HMNXSV003015436
ILMN_1793433
PH_hs_0008203
PH_hs_0012838
TC02000146.hg
g12052825_3p_at
g12654156_3p_a_at
Participates
as a component of
GGC-RAB10:GDP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB10:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
as a member of
GGC-RAB8A,10,13,14 [cytoplasmic vesicle membrane] (Homo sapiens)
Other forms of this molecule
GGC-RAB10 [cytosol]
RAB10 [cytosol]
RAB10 [plasma membrane]
RAB10 [secretory granule membrane]
Inferred To
GGC-RAB10 [cytoplasmic vesicle membrane]
(Caenorhabditis elegans)
GGC-RAB10 [cytoplasmic vesicle membrane]
(Gallus gallus)
GGC-RAB10 [cytoplasmic vesicle membrane]
(Rattus norvegicus)
GGC-Rab10 [cytoplasmic vesicle membrane]
(Mus musculus)
rab10 [cytoplasmic vesicle membrane]
(Danio rerio)
rab10 [cytoplasmic vesicle membrane]
(Xenopus tropicalis)
Rab10 [cytoplasmic vesicle membrane]
(Drosophila melanogaster)
RAB10 [cytoplasmic vesicle membrane]
(Bos taurus)
RAB10 [cytoplasmic vesicle membrane]
(Canis familiaris)
RAB10 [cytoplasmic vesicle membrane]
(Sus scrofa)
Modified Residues
Name
S-geranylgeranyl-L-cysteine at 199
Coordinate
199
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Name
S-geranylgeranyl-L-cysteine at 200
Coordinate
200
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Cross References
RefSeq
NP_057215.3
OpenTargets
ENSG00000084733
GeneCards
P61026
HPA
ENSG00000084733-RAB10
Ensembl
ENSG00000084733
,
ENST00000264710
,
ENSP00000264710
PRO
P61026
Pharos - Targets
P61026
PDB
5SZJ
,
5LPN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.688
7
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.556
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:P24386 CHM
1
CHM [cytosol]
(R-HSA-6801097)
0.527
3
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