Reactome: A Curated Pathway Database

InlB:MET dimer trans-autophophorylates

Stable Identifier
R-HSA-8876230
Type
Reaction
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Locations in the PathwayBrowser
Summation

MET bound to Listeria monocytogenes InlB protein undergoes trans-autophosphorylation. Phosphorylation at tyrosine residues Y1234 and Y1235 in the activation loop of the kinase domain of MET was specifically demonstrated. As InlB-activated MET activates downstream signaling by ERKs (MAPKs) and PI3K/AKT, MET is presumably phosphorylated on GRB2 and GAB1 docking sites Y1349 and Y1356, respectively (Niemann et al. 2007, Ferraris et al. 2010).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of InlB:MET dimer [plasma membrane] InlB:MET dimer [plasma membrane] protein tyrosine kinase activity (0004713)
Disease
Diseases
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis