InlB-activated MET phosphorylates CBL

Stable Identifier
R-HSA-8876246
Type
Reaction
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Locations in the PathwayBrowser
Summation

Binding of InlB to MET receptor induces CBL phosphorylation on tyrosine residue(s). Based on the analogy with HGF-induced MET signaling, MET receptor activated by binding of the Listeria monocytogenes protein InlB phosphorylates CBL, promoting stronger interaction of CBL with MET (Peschard et al. 2001, Petrelli et al. 2002).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of InlB:p-4Y-MET dimer:GRB2-1:CBL [plasma membrane, cell wall]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis