CBL recruits CIN85:endophilin complex to InlB-bound MET

Stable Identifier
R-HSA-8876255
Type
Reaction
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Locations in the PathwayBrowser
Summation

CIN85 is necessary for endocytosis-mediated entry of Listeria monocytogenes triggered by CBL-mediated monoubiquitination of MET receptor activated by binding to the bacterial cell wall protein InlB (Veiga et al. 2005). Based on the analogy with HGF-activated MET signaling (Petrelli et al. 2002), CBL recruits the complex of CIN85 and endophilin to Listeria-engaged MET.

Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells Nat. Cell Biol. 2005
Participants
Participant Of
Inferred From
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis