CBL recruits CIN85:endophilin complex to InlB-bound MET

Stable Identifier
R-HSA-8876255
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, peptidoglycan-based cell wall, cytosol
ReviewStatus
5/5
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CBL recruits CIN85:endophilin complex to InlB-bound MET
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CIN85 is necessary for endocytosis-mediated entry of Listeria monocytogenes triggered by CBL-mediated monoubiquitination of MET receptor activated by binding to the bacterial cell wall protein InlB (Veiga et al. 2005). Based on the analogy with HGF-activated MET signaling (Petrelli et al. 2002), CBL recruits the complex of CIN85 and endophilin to Listeria-engaged MET.
Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
Participants
Input
Output
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as an event of
Inferred From
CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)
Disease
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Orlic-Milacic, M  (2016-06-10)
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