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CBL monoubiquitinates InlB-bound MET

Stable Identifier
R-HSA-8876258
Type
Reaction
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Locations in the PathwayBrowser
Summation

CBL promotes monoubiquitination of MET receptor that is activated by binding of the Listeria monocytogenes cell wall protein InlB. CBL-mediated monoubiquitination of MET promotes endocytosis and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).

Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells Nat. Cell Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of InlB:p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall]
Physical Entity
Activity
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis