Proteins involved in clathrin-mediated endocytosis EPS15 and HGS (Hrs) are both necessary for CBL and MET-mediated entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005). Based on the analogy with HGF-activated MET signaling (Bache et al. 2003, Row et al. 2005, Parachoniak et al. 2009), HGS and EPS15, in complex with STAM proteins, bind to MET receptor monoubiquitinated by CBL upon MET receptor activation by the Listeria monocytogenes InlB protein.