EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB

Stable Identifier
R-HSA-8876262
Type
Reaction
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Locations in the PathwayBrowser
Summation

Proteins involved in clathrin-mediated endocytosis EPS15 and HGS (Hrs) are both necessary for CBL and MET-mediated entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005). Based on the analogy with HGF-activated MET signaling (Bache et al. 2003, Row et al. 2005, Parachoniak et al. 2009), HGS and EPS15, in complex with STAM proteins, bind to MET receptor monoubiquitinated by CBL upon MET receptor activation by the Listeria monocytogenes InlB protein.

Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells Nat. Cell Biol. 2005
Participants
Participant Of
Inferred From
Authored
Reviewed
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis