There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

DENND3 exchanges GTP for GDP on RAB12

Stable Identifier
R-HSA-8876454
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DENND3 is a RAB12-specific GEF with roles in macroautophagy and the trafficking of proteins from the recycling endosome to the lysosome (Yoshimura et al, 2010; Matsui et al, 2014; Xu et al, 2015; reviewed in Xu and McPherson, 2015). DENND3 activity promotes the formation of active RAB12:GTP, required for the constitutive degradation of plasma membrane proteins such as the transferrin receptor and the amino acid transporter SLC36A4, also known as PAT4 (Matsui et al, 2011; Matsui and Fukuda, 2013; Matsui et al, 2014; Sirohi et al, 2013). Under starvation conditions, DENND3 is phosphorylated by the macroautophagy-promoting kinase ULK1. DENND3- and RAB12-dependent degradation of SLC36A4 contributes to the activation of the macroautophagy pathway by decreasing intracellular amino-acid levels and inhibiting mTORC1 (Matsui and Fukuda, 2013; Matsui et al, 2014; Xu et al, 2015; Fan et al, 2016; reviewed in Xu and McPherson, 2015).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rab guanyl-nucleotide exchange factor activity of DENND3 [cytosol]
Physical Entity
Activity
Orthologous Events