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DENND6A,B exchange GTP for GDP on RAB14

Stable Identifier
R-HSA-8876616
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RAB14 is involved in the trafficking of GLUT4 to the plasma membrane and also contributes to cell migration by regulating the trafficking of ADAM10, a metalloendopetidase that cleaves a number of cell surface proteins including the adherens junction components N-cadherin (Reed et al, 2013; Brewer et al, 2016; Linford et al, 2012; Lu et al, 2012; Maretzky et al, 2005; Reiss et al, 2005; Gutwein et al, 2010; Rabquer et al, 2010). DENND6A and B, also known as FAM116A and B, show RAB14 GEF activity in vitro and are required for RAB14 localization and activity in vivo (Linford et al, 2012; reviewed in Ishida et al, 2016). Interaction of RAB14:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB14 with GDI and CHM proteins.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rab guanyl-nucleotide exchange factor activity of DENND6A,B [cytosol]
Physical Entity
Activity
Orthologous Events