Reactome | DENND6A,B exchange GTP for GDP on RAB14

DENND6A,B exchange GTP for GDP on RAB14

Stable Identifier

R-HSA-8876616

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, recycling endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAB14 is involved in the trafficking of GLUT4 to the plasma membrane and also contributes to cell migration by regulating the trafficking of ADAM10, a metalloendopetidase that cleaves a number of cell surface proteins including the adherens junction components N-cadherin (Reed et al, 2013; Brewer et al, 2016; Linford et al, 2012; Lu et al, 2012; Maretzky et al, 2005; Reiss et al, 2005; Gutwein et al, 2010; Rabquer et al, 2010). DENND6A and B, also known as FAM116A and B, show RAB14 GEF activity in vitro and are required for RAB14 localization and activity in vivo (Linford et al, 2012; reviewed in Ishida et al, 2016). Interaction of RAB14:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB14 with GDI and CHM proteins.

Literature References

PubMed ID	Title	Journal	Year
26936971	Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes Brewer, PD, Habtemichael, EN, Romenskaia, I, Coster, AC, Mastick, CC	Biochem. J.	2016
23444368	A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes Reed, SE, Hodgson, LR, Song, S, May, MT, Kelly, EE, McCaffrey, MW, Mastick, CC, Verkade, P, Tavaré, JM	J. Cell. Sci.	2013
15692570	ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling Reiss, K, Maretzky, T, Ludwig, A, Tousseyn, T, De Strooper, B, Hartmann, D, Saftig, P	EMBO J.	2005
12475894	ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles Gutwein, P, Mechtersheimer, S, Riedle, S, Stoeck, A, Gast, D, Joumaa, S, Zentgraf, H, Fogel, M, Altevogt, DP	FASEB J.	2003
20592283	Junctional adhesion molecule-C is a soluble mediator of angiogenesis Rabquer, BJ, Amin, MA, Teegala, N, Shaheen, MK, Tsou, PS, Ruth, JH, Lesch, CA, Imhof, BA, Koch, AE	J. Immunol.	2010
15958533	ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation Maretzky, T, Reiss, K, Ludwig, A, Buchholz, J, Scholz, F, Proksch, E, De Strooper, B, Hartmann, D, Saftig, P	Proc. Natl. Acad. Sci. U.S.A.	2005
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014
24694596	Rab14 regulation of claudin-2 trafficking modulates epithelial permeability and lumen morphogenesis Lu, R, Johnson, DL, Stewart, L, Waite, K, Elliott, D, Wilson, JM	Mol. Biol. Cell	2014
27246931	Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases Ishida, M, Oguchi, ME, Fukuda, M	Cell Struct. Funct.	2016
22595670	Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells Linford, A, Yoshimura, S, Nunes Bastos, R, Langemeyer, L, Gerondopoulos, A, Rigden, DJ, Barr, FA	Dev. Cell	2012