Protein methylation

Stable Identifier
R-HSA-8876725
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Methylation of lysine (Lys) and arginine (Arg) residues on non-histone proteins is a prevalent post-translational modification and important regulator of cellular signal transduction pathways including MAPK, WNT, BMP, Hippo and JAK?STAT. Crosstalk between methylation and other types of post-translational modifications and between histone and non-histone protein methylation is frequent, affecting cellular functions such as chromatin remodelling, gene transcription, protein synthesis, signal transduction and DNA repair (Biggar & Li 2015).

Literature References
PubMed ID Title Journal Year
25491103 Non-histone protein methylation as a regulator of cellular signalling and function Nat. Rev. Mol. Cell Biol. 2015
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Event Information
Go Biological Process
Orthologous Events