CARNMT1 methylates CARN to Anserine

Stable Identifier
R-HSA-8876789
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Anserine (Beta-alanyl-N(Pi)-methyl-L-histidine) is a methylated derivative of carnosine (Beta-alanyl-L-histidine) and an abundant constituent of vertebrate skeletal muscles (Boldyrev et al. 2013). It has been suggested to serve as a proton buffer and radical scavenger. The formation of anserine is catalyzed by carnosine N-methyltransferase (CARNMT1), which transfers a methyl group from S-adenosyl-L-methionine (SAM) onto the nitrogen atom (Pi) of L-histidine residue in carnosine (Drozak et al. 2015). While CARNMT1 produces anserine in mammals, a similar reaction is catalysed by a different enzyme (carnosine N-methyltransferase 2) in birds and reptiles (Drozak et al. 2013).

Literature References
PubMed ID Title Journal Year
26001783 UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase

Drozak, J, Piecuch, M, Poleszak, O, Kozlowski, P, Chrobok, L, Baelde, HJ, de Heer, E

J. Biol. Chem. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
carnosine N-methyltransferase activity of CARNMT1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created