Reactome | p-Y753,Y754-CDH1(155-882) [plasma membrane]

p-Y753,Y754-CDH1(155-882) [plasma membrane]

Stable Identifier

R-HSA-8876938

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P12830 CDH1

Gene Names

CDH1, CDHE, UVO

Chain

signal peptide:1-22, propeptide:23-154, chain:155-882, chain:701-882, chain:732-882, chain:751-882

Reference Genes

BioGPS Gene:999 CDH1

COSMIC (genes):CDH1 CDH1

CTD Gene:999 CDH1

dbSNP Gene:999 CDH1

ENSEMBL:ENSG00000039068 CDH1

HGNC:1748 CDH1

KEGG Gene (Homo sapiens):999 CDH1

Monarch:999 CDH1

NCBI Gene:999 CDH1

OMIM:192090 CDH1

UCSC:P12830 CDH1

Reference Transcript

Other Identifiers

0001050066

11716905_a_at

11716906_a_at

16820486

201130_s_at

201131_s_at

2082_s_at

3666410

3666411

3666412

3666427

3666430

3666431

3666432

3666433

3666435

3666437

3666438

3666442

3666444

3666445

3666450

3666451

3666452

3666453

3666454

3666455

3666459

7996837

977_s_at

999

A_23_P206359

GE57732

GO:0003674

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0005794

GO:0005802

GO:0005856

GO:0005886

GO:0005912

GO:0006810

GO:0006913

GO:0007155

GO:0007156

GO:0007267

GO:0007416

GO:0008013

GO:0008092

GO:0008150

GO:0009056

GO:0009058

GO:0009636

GO:0009898

GO:0010033

GO:0010468

GO:0015031

GO:0015629

GO:0016020

GO:0016021

GO:0016328

GO:0016342

GO:0016600

GO:0021983

GO:0022408

GO:0022607

GO:0030027

GO:0030054

GO:0030154

GO:0030198

GO:0030336

GO:0030506

GO:0030864

GO:0031175

GO:0031410

GO:0032794

GO:0032991

GO:0034330

GO:0034332

GO:0034641

GO:0035635

GO:0040011

GO:0042307

GO:0042493

GO:0042802

GO:0043167

GO:0043226

GO:0043296

GO:0044403

GO:0045295

GO:0045296

GO:0045893

GO:0046872

GO:0048471

GO:0048856

GO:0048870

GO:0050839

GO:0070062

GO:0071285

GO:0071681

GO:0072659

GO:0098609

GO:0098742

GO:0098794

GO:0098978

GO:0099576

HMNXSV003039550

ILMN_1724815

ILMN_1770940

PH_hs_0011491

TC16000559.hg

Z35402_rna1_s_at

g340184_3p_a_at

g4757959_3p_a_at

Participates

as a component of

p-Y753,Y754-CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

CDH1(732-882) [plasma membrane]

CDH1(751-882) [plasma membrane]

CDH1(155-750) [plasma membrane]

CDH1(155-700) [plasma membrane]

CDH1(701-882) [extracellular region]

Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]

CDH1(155-750) [plasma membrane]

CDH1(751-882) [plasma membrane]

CDH1(155-882) [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at 753

Coordinate

753

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 754

Coordinate

754

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001304114.1, NP_001304113.1, NP_001304115.1, NP_004351.1

OpenTargets

ENSG00000039068

GeneCards

P12830

HPA

ENSG00000039068-CDH1

Ensembl

ENST00000422392, ENSP00000261769, ENSG00000039068, ENSP00000414946, ENST00000261769

PRO

P12830

Pharos - Targets

P12830

GlyGen

P12830

Orphanet

15419

HMDB Protein

HMDBP02891

PDB

6OLF, 2OMV, 3FF8, 3L6X, 2OMX, 3L6Y, 6VEL, 6OLG, 6CXY, 4ZTE, 2OMT, 2OMY, 4ZT1, 2OMU, 2OMZ, 1O6S, 2O72, 3FF7, 6OLE

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.949	15
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.875	7
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.748	6
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.735	4
UniProt:P0DJM0 inlA	1	InlA [cell wall] (R-LMO-8876505)	0.683	3
UniProt:Q9JIY2	1	Cbll1 [cytosol] (R-MMU-8851646)	0.645	21
UniProt:Q6IQ23 PKHA7			0.602	4
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.589	2
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.571	7
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:O94983-5 CAMTA2			0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [specific granule lumen] (R-HSA-6799554) DNASE1L1 [extracellular region] (R-HSA-6806320)	0.556	3
UniProt:Q8NCR3 MFI			0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:Q8TB02 Q8TB02			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q8N323 NXPE1			0.556	3
UniProt:Q8N2W9 PIAS4	2	SUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415) PIAS4 [nucleoplasm] (R-HSA-2993789)	0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q6UXH1-2 CRELD2			0.556	3
UniProt:Q7Z6Z7-2 HUWE1			0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [nucleoplasm] (R-HSA-2564700) TPX2 [cytosol] (R-HSA-8853407)	0.556	3
UniProt:P17612 PRKACA	3	PRKACA [cytosol] (R-HSA-57844) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936)	0.556	3
UniProt:P11362 FGFR1	8	FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361)	0.536	3
UniProt:P33724	4	CAV1 [endocytic vesicle membrane] (R-CFA-535009) CAV1 [Golgi membrane] (R-CFA-204504) CAV1 [early endosome membrane] (R-CFA-5368451) CAV1 [plasma membrane] (R-CFA-534994)	0.525	2
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.524	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.499	2
UniProt:Q9H8V3 ECT2	1	ECT2 [cytosol] (R-HSA-195036)	0.499	3
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.499	2
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.499	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.499	2

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