Reactome: A Curated Pathway Database

MADD exchanges GTP for GDP on RAB27

Stable Identifier
R-HSA-8877308
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Vertebrate RAB27 exists in two isoforms, RAB27A and RAB27B, with overlapping but distinct functions in trafficking to melanosomes, secretory granules and platelets (Kondo et al, 2006; Figueiredo et al, 2008; Tarafder et al, 2011; reviewed in Fukuda et al, 2013). Studies in nematodes and vertebrates have identified MADD as a RAB27 GEF required for its activity (Mahoney et al, 2006; Tarafder et al, 2011; Yoshimura et al, 2010). Interaction of RAB27:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB27 with GDI and CHM proteins.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Rab guanyl-nucleotide exchange factor activity of MADD [cytosol] MADD [cytosol] Rab guanyl-nucleotide exchange factor activity (0017112)
Orthologous Events