Reactome: A Curated Pathway Database

RAB31 GEFs exchange GTP for GDP on RAB31

Stable Identifier
R-HSA-8877311
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RAB31, also referred to as RAB22B, is a member of the RAB5 family of proteins (Chen et al, 1996; Bao et al, 2002). It is involved in trafficking pathways at the trans-Golgi network (TGN) and early endosome, where it is required for insulin-stimulated GLUT4 transport, internalization of the EGFR receptor and for mannose-6-phosphate receptor transport from the TGN (Rodriguez-Gabin et al, 2001; Lodhi et al, 2007; Chua et al, 2014; Ng et al, 2007; Ng et al, 2009; Rodriguez-Gabin et al, 2009). RAB31 overexpression is also implicated in cellular proliferation and apoptosis during cancer progression (Pan et al, 2015; reviewed in Chua and Tang, 2015). RAB31 is activated by VPS domain-containing GEFs GAPVD1 (also known as GAPEX5 or RAP6) and RIN3 (Hunker et al, 2006; Lodhi et al, 2007; Kajiho et al, 2003; Kajiho et al, 2011). Interaction of RAB31:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB31 with GDI and CHM proteins.

Literature References
PubMed ID Title Journal Year
8863739 Molecular cloning of two novel rab genes from human melanocytes Gene 1996
12972505 RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway J. Cell. Sci. 2003
25472813 The role of the small GTPase Rab31 in cancer J. Cell. Mol. Med. 2015
24644286 Engagement of the small GTPase Rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome J. Biol. Chem. 2014
17189207 Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes Cell Metab. 2007
19345684 Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31 Exp. Cell Res. 2009
21586568 Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31 J. Biol. Chem. 2011
19725050 Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells J. Cell. Physiol. 2009
26245486 The Critical Role of Rab31 in Cell Proliferation and Apoptosis in Cancer Progression Mol. Neurobiol. 2015
17678623 Rab22B's role in trans-Golgi network membrane dynamics Biochem. Biophys. Res. Commun. 2007
11746448 Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments J. Neurosci. Res. 2001
11784320 Molecular cloning, bacterial expression and properties of Rab31 and Rab32 Eur. J. Biochem. 2002
16410077 Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis Biochem. Biophys. Res. Commun. 2006
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Rab guanyl-nucleotide exchange factor activity of RAB31 GEFs [cytosol] RAB31 GEFs [cytosol] Rab guanyl-nucleotide exchange factor activity (0017112)
Orthologous Events