IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3

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R-HSA-8877345
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Reaction [omitted]
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Homo sapiens
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The RUNX1:CBFB complex in cooperation with NFATC2 (NFAT1) stimulates transcription of the IL2 gene. In the presence of FOXP3, however, transcription of the IL2 gene is suppressed. Suppressed IL2 production is one of the hallmarks of regulatory T cells (Tregs) (Wu et al. 2006, Ono et al. 2007).

Literature References
PubMed ID Title Journal Year
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M, Yaguchi, H, Ohkura, N, Kitabayashi, I, Nagamura, Y, Nomura, T, Miyachi, Y, Tsukada, T, Sakaguchi, S

Nature 2007
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Wu, Y, Borde, M, Heissmeyer, V, Feuerer, M, Lapan, AD, Stroud, JC, Bates, DL, Guo, L, Han, A, Ziegler, SF, Mathis, D, Benoist, C, Chen, L, Rao, A

Cell 2006
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