RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter

Stable Identifier
R-HSA-8877348
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The complex of FOXP3 and RUNX1 (RUNX1 being consitutively associated with CBFB) can bind to the IL2 gene promoter in cooperation with NFATC2 (NFAT1). The NFAT response element is adjacent to RUNX1 response element in the IL2 promoter (Wu et al. 2006, Ono et al. 2007).

Literature References
PubMed ID Title Journal Year
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M, Yaguchi, H, Ohkura, N, Kitabayashi, I, Nagamura, Y, Nomura, T, Miyachi, Y, Tsukada, T, Sakaguchi, S

Nature 2007
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Wu, Y, Borde, M, Heissmeyer, V, Feuerer, M, Lapan, AD, Stroud, JC, Bates, DL, Guo, L, Han, A, Ziegler, SF, Mathis, D, Benoist, C, Chen, L, Rao, A

Cell 2006
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