IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1

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R-HSA-8877396
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Reaction [omitted]
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Homo sapiens
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The RUNX1:CBFB complex inhibits transcription of the IL2RA (CD25) gene. Once FOXP3 binds to RUNX1, transcription of the IL2RA gene is stimulated. High IL2RA expression at the cell surface is one of the hallmarks of regulatory T cells (Tregs) (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M, Yaguchi, H, Ohkura, N, Kitabayashi, I, Nagamura, Y, Nomura, T, Miyachi, Y, Tsukada, T, Sakaguchi, S

Nature 2007
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Wu, Y, Borde, M, Heissmeyer, V, Feuerer, M, Lapan, AD, Stroud, JC, Bates, DL, Guo, L, Han, A, Ziegler, SF, Mathis, D, Benoist, C, Chen, L, Rao, A

Cell 2006
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