CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1

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R-HSA-8877421
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Reaction [omitted]
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Homo sapiens
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Binding of the RUNX1:CBFB complex to the promoter of the CTLA4 gene inhibits CTLA4 transcription. Once FOXP3 is associated with RUNX1, the CTLA4 gene transcription is stimulated. High cells surface level of CTLA4 is one of the hallmarks of regulatory T cells (T regs) (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M, Yaguchi, H, Ohkura, N, Kitabayashi, I, Nagamura, Y, Nomura, T, Miyachi, Y, Tsukada, T, Sakaguchi, S

Nature 2007
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Wu, Y, Borde, M, Heissmeyer, V, Feuerer, M, Lapan, AD, Stroud, JC, Bates, DL, Guo, L, Han, A, Ziegler, SF, Mathis, D, Benoist, C, Chen, L, Rao, A

Cell 2006
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