PIN1 binds phosphorylated PIP4K2B

Stable Identifier
R-HSA-8877692
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Peptidyl-prolyl cis-trans isomerase PIN1 binds to PIP4K2B phosphorylated at serine residue S326. PIP4K2B is phosphorylated at S326 under conditions of cellular stress, such as increased level of reactive oxygen species (ROS). Phosphorylation of PIP4K2B at threonine residue T322 may also contribute to PIN1 binding. PIN1 induces conformational change of PIP4K2B, resulting in inactivation of PIP4K2B dimers. This enables increase of the nuclear PI5P levels. PI5P positively regulates expression of genes involved in neutralization of ROS (Keune et al. 2012).

Literature References
PubMed ID Title Journal Year
23193159 Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress

Keune, WJ, Jones, DR, Bultsma, Y, Sommer, L, Zhou, XZ, Lu, KP, Divecha, N

Sci Signal 2012
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