RUNX1 and FOXP3 stimulate the RSPO3 gene expression

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R-HSA-8877884
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Reaction [omitted]
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Homo sapiens
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Binding of the RUNX1:CBFB complex and FOXP3 to the promoter of the RSPO3 gene stimulates RSPO3 transcription. RSPO3 functions as a WNT ligand and is a known breast cancer oncogene (Recouvreux et al. 2016).

Literature References
PubMed ID Title Journal Year
26735887 RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes

Recouvreux, MS, Grasso, EN, Echeverria, PC, Rocha-Viegas, L, Castilla, LH, Schere-Levy, C, Tocci, JM, Kordon, EC, Rubinstein, N

Oncotarget 2016
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