HIPK2 phosphorylates RUNX1

Stable Identifier
R-HSA-8878054
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Protein serine/threonine kinase HIPK2 phosphorylates RUNX1 upon formation of the RUNX1:CBFB complex. Serine residues S249 and S273 and threonine residue S276 of RUNX1 are phosphorylated by HIPK2. HIPK2-mediated phosphorylation of RUNX1 is implicated as an important regulatory step in hematopoiesis and is disrupted by leukemogenic mutations in CBFB (Aikawa et al. 2006, Wee et al. 2008).

Literature References
PubMed ID Title Journal Year
16917507 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

Aikawa, Y, Nguyen, LA, Isono, K, Takakura, N, Tagata, Y, Schmitz, ML, Koseki, H, Kitabayashi, I

EMBO J. 2006
18695000 PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

Wee, HJ, Voon, DC, Bae, SC, Ito, Y

Blood 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of HIPK2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created