RUNX1:CBFB binds EP300

Stable Identifier
R-HSA-8878056
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The complex of CBFB and RUNX1 can bind histone acetyltransferase EP300 (p300). Formation of this complex does not depend on HIPK2-mediated phosphorylation of RUNX1. Histone acetyltransferase activity of EP300 probably contributes to transcriptional activation of RUNX1:CBFB target genes (Aikawa et al. 2006, Wee et al. 2008).

Literature References
PubMed ID Title Journal Year
16917507 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

Aikawa, Y, Nguyen, LA, Isono, K, Takakura, N, Tagata, Y, Schmitz, ML, Koseki, H, Kitabayashi, I

EMBO J. 2006
18695000 PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

Wee, HJ, Voon, DC, Bae, SC, Ito, Y

Blood 2008
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