The complex of CBFB and RUNX1 can bind histone acetyltransferase EP300 (p300). Formation of this complex does not depend on HIPK2-mediated phosphorylation of RUNX1. Histone acetyltransferase activity of EP300 probably contributes to transcriptional activation of RUNX1:CBFB target genes (Aikawa et al. 2006, Wee et al. 2008).