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p-S249,S273,T276-RUNX1 [nucleoplasm]
Stable Identifier
R-HSA-8878063
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S249,S273,T276-AML1
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
HIPK2 phosphorylates RUNX1 (Homo sapiens)
p-S249,S273,T276-RUNX1:CBFB [nucleoplasm] (Homo sapiens)
p-S249,S273,T276-RUNX1 [nucleoplasm] (Homo sapiens)
HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)
p-S249,S273,T276-RUNX1:CBFB:p-S,T-EP300 [nucleoplasm] (Homo sapiens)
p-S249,S273,T276-RUNX1:CBFB [nucleoplasm] (Homo sapiens)
p-S249,S273,T276-RUNX1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01196 RUNX1
Gene Names
RUNX1, AML1, CBFA2
Chain
chain:1-453
Reference Genes
BioGPS Gene:861 RUNX1
COSMIC (genes):RUNX1 RUNX1
CTD Gene:861 RUNX1
dbSNP Gene:861 RUNX1
ENSEMBL:ENSG00000159216 RUNX1
HGNC:10471 RUNX1
KEGG Gene (Homo sapiens):861 RUNX1
Monarch:861 RUNX1
NCBI Gene:861 RUNX1
OMIM:151385 RUNX1
UCSC:Q01196 RUNX1
Reference Transcript
RefSeq:NM_001001890.2 RUNX1
RefSeq:XM_005261068.3 RUNX1
RefSeq:NM_001122607.1 RUNX1
RefSeq:NM_001754.4 RUNX1
RefSeq:XM_011529766.2 RUNX1
Other Identifiers
0001500338
100506403
11728761_a_at
11728762_x_at
11732933_a_at
11742191_a_at
11745150_x_at
11753289_s_at
11762910_x_at
2026_at
208129_x_at
209359_x_at
209360_s_at
210365_at
210805_3p_x_at
210805_x_at
211180_x_at
211181_x_at
211182_x_at
211620_3p_x_at
211620_x_at
3930361
3930362
3930363
3930364
3930365
3930366
3930367
3930373
3930392
3930393
3930404
3930405
3930411
3930427
3930428
3930433
3930434
3930435
3930436
3930437
3930438
3930439
3930440
3930441
3930442
3930443
3930444
3930446
3930506
3930507
3930508
3930509
3930510
3930529
393_s_at
39421_at
8070194
861
943_at
A_24_P34155
A_24_P96403
A_33_P3211804
A_33_P3211809
A_33_P3211818
D43968_at
GE57221
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001503
GO:0001959
GO:0002062
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006355
GO:0006357
GO:0007155
GO:0007165
GO:0007267
GO:0008134
GO:0008150
GO:0008283
GO:0009058
GO:0010629
GO:0010755
GO:0016513
GO:0022607
GO:0030097
GO:0030099
GO:0030111
GO:0030154
GO:0030182
GO:0030198
GO:0030854
GO:0032743
GO:0032967
GO:0032991
GO:0033146
GO:0034330
GO:0034641
GO:0040007
GO:0042803
GO:0043167
GO:0043226
GO:0043231
GO:0043371
GO:0043378
GO:0045589
GO:0045595
GO:0045616
GO:0045637
GO:0045652
GO:0045766
GO:0045893
GO:0045944
GO:0046982
GO:0048646
GO:0048856
GO:0048935
GO:0050855
GO:0051604
GO:0060043
GO:0061026
GO:0071425
GO:1902036
GO:1903055
GO:1905203
GO:2000810
HMNXSV003004846
HMNXSV003013956
ILMN_1654941
ILMN_1669335
ILMN_1730797
ILMN_1801504
PH_hs_0041180
X90976_s_at
g1752816_3p_a_at
g1932819_3p_a_at
g1932819_3p_x_at
g966994_3p_at
g966996_3p_a_at
Participates
as a component of
p-S249,S273,T276-RUNX1:CBFB [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RUNX1 [plasma membrane]
p-7Y-RUNX1 [nucleoplasm]
RUNX1 [nucleoplasm]
MeR206,MeR210-RUNX1 [nucleoplasm]
Inferred To
phospho-RunxB [nucleoplasm]
(Drosophila melanogaster)
phospho-RUNX1 [nucleoplasm]
(Gallus gallus)
phospho-RUNX1 [nucleoplasm]
(Sus scrofa)
phospho-runx1 [nucleoplasm]
(Danio rerio)
Homologues of p-S249,S273,T276-RUNX1 [nucleoplasm]
(Drosophila melanogaster)
phospho-Runx1 [nucleoplasm]
(Mus musculus)
phospho-Runx1 [nucleoplasm]
(Rattus norvegicus)
phospho-run [nucleoplasm]
(Drosophila melanogaster)
phospho-lz [nucleoplasm]
(Drosophila melanogaster)
phospho-RunxA [nucleoplasm]
(Drosophila melanogaster)
phospho-rnt-1 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 249
Coordinate
249
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 273
Coordinate
273
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 276
Coordinate
276
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001745.2
,
NP_001116079.1
,
XP_011528068.1
,
NP_001001890.1
,
XP_005261125.1
OpenTargets
ENSG00000159216
HPA
ENSG00000159216-RUNX1
GeneCards
Q01196
Ensembl
ENSG00000159216
,
ENST00000344691
,
ENST00000437180
,
ENSP00000340690
,
ENST00000358356
,
ENSP00000300305
,
ENST00000300305
,
ENSP00000351123
,
ENSP00000409227
PRO
Q01196
Orphanet
15235
PDB
1LJM
,
1CMO
,
1E50
,
1CO1
,
1H9D
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.713
3
UniProt:Q9H2X6 HIPK2
3
p-HIPK2 [nucleoplasm]
(R-HSA-6799375)
SUMO1-K32-HIPK2 [nucleoplasm]
(R-HSA-4090405)
HIPK2 [nucleoplasm]
(R-HSA-3215222)
0.639
4
UniProt:Q00534 CDK6
3
CDK6 [nucleoplasm]
(R-HSA-141283)
CDK6 [cytosol]
(R-HSA-68336)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.628
5
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.623
3
UniProt:Q15723 ELF2
1
ELF2 [nucleoplasm]
(R-HSA-8938898)
0.544
2
UniProt:Q9GZV5 WWTR1
3
WWTR1 [nucleoplasm]
(R-HSA-1629775)
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
WWTR1 [cytosol]
(R-HSA-1629773)
0.527
2
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