Reactome | p-S,T-EP300 [nucleoplasm]

p-S,T-EP300 [nucleoplasm]

Stable Identifier

R-HSA-8878072

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S,T-p300

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)
        
        p-S249,S273,S276-RUNX1:CBFB:p-S,T-EP300 [nucleoplasm] (Homo sapiens)
        
        p-S,T-EP300 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q09472 EP300

Gene Names

EP300, P300

Chain

initiator methionine:, chain:2-2414

Reference Genes

BioGPS Gene:2033 EP300

COSMIC (genes):EP300 EP300

CTD Gene:2033 EP300

dbSNP Gene:2033 EP300

ENSEMBL:ENSG00000100393 EP300

ENSEMBL_homo_sapiens_GENE:ENSG00000100393.15 EP300

HGNC:3373 EP300

KEGG Gene (Homo sapiens):2033 EP300

Monarch:2033 EP300

NCBI Gene:2033 EP300

OMIM:602700 EP300

UCSC:Q09472 EP300

Reference Transcript

RefSeq:NM_001429.3 EP300

Other Identifiers

11725127_at

16930534

17119320

202221_PM_s_at

202221_s_at

2033

213579_PM_s_at

213579_s_at

33896_at

3946616

3946617

3946618

3946619

3946627

3946629

3946631

3946632

3946634

3946637

3946638

3946640

3946641

3946642

3946643

3946645

3946646

3946649

3946651

3946652

3946653

3946655

3946656

3946657

3946658

3946660

3946665

3946667

3946669

3946671

3946672

3946673

3946674

3946675

3946676

3946677

3946678

3946679

3946682

3946683

3946684

3946685

3946686

3946687

3946688

3946689

3946690

3946691

551_at

8073345

A_14_P108084

A_14_P127141

A_23_P40693

A_24_P7887

GE58850

GO:0000122

GO:0000123

GO:0000785

GO:0001221

GO:0001223

GO:0001666

GO:0001756

GO:0001966

GO:0002039

GO:0002209

GO:0002223

GO:0002376

GO:0003677

GO:0003682

GO:0003684

GO:0003712

GO:0003713

GO:0003723

GO:0003824

GO:0004402

GO:0004468

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006110

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006473

GO:0006475

GO:0006886

GO:0006913

GO:0006914

GO:0006915

GO:0007005

GO:0007049

GO:0007249

GO:0007399

GO:0007507

GO:0007519

GO:0007611

GO:0007623

GO:0008013

GO:0008092

GO:0008270

GO:0009887

GO:0010484

GO:0010485

GO:0010506

GO:0010507

GO:0010628

GO:0010742

GO:0010821

GO:0010976

GO:0012501

GO:0016407

GO:0016573

GO:0016740

GO:0016746

GO:0016922

GO:0018076

GO:0018393

GO:0018394

GO:0023052

GO:0030154

GO:0030183

GO:0030220

GO:0030324

GO:0030511

GO:0031333

GO:0031490

GO:0031648

GO:0031669

GO:0032991

GO:0032993

GO:0034212

GO:0034644

GO:0035264

GO:0035855

GO:0036211

GO:0036268

GO:0042307

GO:0042771

GO:0043226

GO:0043627

GO:0043923

GO:0043993

GO:0044013

GO:0044017

GO:0044877

GO:0045444

GO:0045721

GO:0045815

GO:0045893

GO:0045944

GO:0046427

GO:0046872

GO:0048156

GO:0048511

GO:0048856

GO:0050681

GO:0050821

GO:0050877

GO:0050896

GO:0051059

GO:0051091

GO:0051604

GO:0055086

GO:0060325

GO:0060765

GO:0061629

GO:0061733

GO:0061920

GO:0061921

GO:0065003

GO:0071233

GO:0090043

GO:0097157

GO:0097677

GO:0098542

GO:0106226

GO:0120300

GO:0120301

GO:0140033

GO:0140064

GO:0140065

GO:0140066

GO:0140067

GO:0140068

GO:0140069

GO:0140096

GO:0140110

GO:0140297

GO:0140908

GO:1900034

GO:1901135

GO:1901796

GO:1904263

HMNXSV003052530

Hs.25272.0.A2_3p_a_at

Hs.25272.1.A1_3p_a_at

ILMN_1744665

PH_hs_0023353

PH_hs_0032399

TC22000332.hg

U01877_at

Participates

as a component of

p-S249,S273,S276-RUNX1:CBFB:p-S,T-EP300 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K1020,1024-EP300 [nucleoplasm]

Foxo4-S-S-EP300 [nucleoplasm]

FOXO4-S-S-EP300 [nucleoplasm]

EP300 [nucleoplasm]

Inferred To

phospho-Ep300 [nucleoplasm] (Rattus norvegicus)

phospho-p-S,T-EP300 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S,T-EP300 [nucleoplasm] (Gallus gallus)

phospho-p-S,T-EP300 [nucleoplasm] (Mus musculus)

phospho-nej [nucleoplasm] (Drosophila melanogaster)

phospho-EP300 [nucleoplasm] (Bos taurus)

phospho-EP300 [nucleoplasm] (Canis familiaris)

phospho-EP300 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001420.2

Guide to Pharmacology - Targets

2735

OpenTargets

ENSG00000100393

ZINC - Substances

EP300_HUMAN

ZINC - Biogenic

EP300_HUMAN

ZINC target

Q09472

PRO

Q09472

PDB

4PZT, 7LJE, 1L3E, 6V90, 4PZS, 6V8N, 7QGS, 8HAH, 8HAI, 4PZR, 2MZD, 8FVF, 3IO2, 8HAG, 6PGU, 5LKU, 5NU5, 5LKT, 3P57, 3T92, 7UGI, 8HAK, 7VI0, 6K4N, 7W9V, 8HAJ, 7VHY, 5KJ2, 7VHZ, 5BT3, 5LKZ, 2K8F, 6FGS, 6GYT, 1P4Q, 6PF1, 6V8K, 7SSK, 4BHW, 6GYR, 5LKX, 8E1D, 6FGN, 8GZC, 6V8B, 7SS8, 7SZQ, 5XZC, 2MH0, 7XFG, 3I3J, 3BIY, 7XEZ, 6DS6, 5LPM, 5LPK

ZINC - Metabolites

EP300_HUMAN

HPA

ENSG00000100393-EP300

GeneCards

Q09472

Ensembl

ENSP00000263253, ENSG00000100393, ENST00000263253

Pharos - Targets

Q09472

Orphanet

15982

ZINC - Predictions - Purchasable

EP300_HUMAN

HMDB Protein

HMDBP00011

Interactors (61)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.976	22
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.962	20
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.784	7
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.734	4
UniProt:P27695 APEX1	1	APEX1 [nucleoplasm] (R-HSA-50119)	0.724	8
UniProt:P03255 E1A			0.702	3
UniProt:P03255-2			0.702	3
UniProt:Q8WXX7 AUTS2	1	AUTS2 [nucleoplasm] (R-HSA-8937967)	0.677	6
UniProt:Q6ZUJ4 CC062			0.671	5
UniProt:Q9QXM1	2	Jmy [nucleoplasm] (R-MMU-6804247) Jmy [nucleoplasm] (R-MMU-6804234)	0.66	16
UniProt:P06790 VE2			0.658	6
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.658	4
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.653	3
UniProt:P03259 E1A			0.646	3
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.623	5
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.61	4
UniProt:P03126 VE6			0.602	8
UniProt:Q9H2X6 HIPK2	3	p-HIPK2 [nucleoplasm] (R-HSA-6799375) HIPK2 [nucleoplasm] (R-HSA-3215222) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.602	4
UniProt:P20265 POU3F2	1	POU3F2 [nucleoplasm] (R-HSA-9613754)	0.602	3
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.602	5
UniProt:P03129 VE7			0.593	14
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.591	4
UniProt:Q9NPI1 BRD7	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.591	3
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.576	3
UniProt:Q01844 EWS			0.573	2
UniProt:P61201 COPS2	2	COPS2 [cytosol] (R-HSA-416971) COPS2 [nucleoplasm] (R-HSA-5697012)	0.558	2
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.558	7
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.553	2
UniProt:P11473 VDR	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.547	3
UniProt:P55209 NP1L1			0.544	3
UniProt:P06422 VE2			0.544	7
UniProt:Q08369 Gata4	2	Gata4 [nucleoplasm] (R-MMU-9692183) Gata4 [nucleoplasm] (R-MMU-400553)	0.544	2
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.536	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.536	2
UniProt:Q9Y463 DYR1B			0.527	2
IntAct:EBI-1550784 CDKN1A			0.527	3
IntAct:EBI-1776214 KLK3			0.527	2
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	3
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.527	2
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.527	2
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.527	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.525	3
UniProt:K4P3M7 K4P3M7			0.524	4
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.524	3
UniProt:P56279 TCL1A			0.524	4
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.524	2
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.508	7
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.508	3
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.499	2
UniProt:P03070 LT			0.499	2
UniProt:Q9UL17 TBX21			0.499	5
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.499	2
UniProt:Q61221	7	Hif1a [cytosol] (R-MMU-1234110) Hif1a [nucleoplasm] (R-MMU-1234105) Hif1a [cytosol] (R-MMU-1234131) phospho-Hif1a [cytosol] (R-MMU-9634700) phospho-Hif1a [cytosol] (R-MMU-8857584) Hif1a [cytosol] (R-MMU-1234102) Hif1a [nucleoplasm] (R-MMU-1234135)	0.499	2
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.499	2
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.488	2
UniProt:P06930 VE6			0.462	2
UniProt:P06428 VE6			0.462	2
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [specific granule lumen] (R-HSA-6799611)	0.462	2
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.462	2

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