RUNX3 binds SMAD3 and SMAD4

Stable Identifier
Reaction [binding]
Homo sapiens
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RUNX3 binds the complex of SMAD3 and SMAD4, formed in response to TGF-beta (TGFB1) signaling (Hanai et al. 1999, Chi et al. 2005).

Literature References
PubMed ID Title Journal Year
10531362 Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

Hanai, J, Chen, LF, Kanno, T, Ohtani-Fujita, N, Kim, WY, Guo, WH, Imamura, T, Ishidou, Y, Fukuchi, M, Shi, MJ, Stavnezer, J, Kawabata, M, Miyazono, K, Ito, Y

J. Biol. Chem. 1999
16135801 RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD

Chi, XZ, Yang, JO, Lee, KY, Ito, K, Sakakura, C, Li, QL, Kim, HR, Cha, EJ, Lee, YH, Kaneda, A, Ushijima, T, Kim, WJ, Ito, Y, Bae, SC

Mol. Cell. Biol. 2005
Participant Of
Orthologous Events
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