The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter

Stable Identifier
R-HSA-8878178
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter
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The CDKN1A (p21) gene promoter contains five putative RUNX3 binding sites. RUNX3 binds the CDKN1A promoter. The complex of SMAD4 and activated SMAD3, a known CDKN1A transcriptional activator, can bind to RUNX3 to cooperatively activate the CDKN1A gene transcription (Chi et al. 2005).

Literature References
PubMed ID Title Journal Year
16135801 RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD

Chi, XZ, Yang, JO, Lee, KY, Ito, K, Sakakura, C, Li, QL, Kim, HR, Cha, EJ, Lee, YH, Kaneda, A, Ushijima, T, Kim, WJ, Ito, Y, Bae, SC

Mol. Cell. Biol. 2005
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Authored
Orlic-Milacic, M  (2016-12-12)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-06-30)