The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter

Stable Identifier
R-HSA-8878178
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The CDKN1A (p21) gene promoter contains five putative RUNX3 binding sites. RUNX3 binds the CDKN1A promoter. The complex of SMAD4 and activated SMAD3, a known CDKN1A transcriptional activator, can bind to RUNX3 to cooperatively activate the CDKN1A gene transcription (Chi et al. 2005).

Literature References
PubMed ID Title Journal Year
16135801 RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD

Chi, XZ, Yang, JO, Lee, KY, Ito, K, Sakakura, C, Li, QL, Kim, HR, Cha, EJ, Lee, YH, Kaneda, A, Ushijima, T, Kim, WJ, Ito, Y, Bae, SC

Mol. Cell. Biol. 2005
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-06-30)
Cite Us!