The CDKN1A (p21) gene promoter contains five putative RUNX3 binding sites. RUNX3 binds the CDKN1A promoter. The complex of SMAD4 and activated SMAD3, a known CDKN1A transcriptional activator, can bind to RUNX3 to cooperatively activate the CDKN1A gene transcription (Chi et al. 2005).
Chi, XZ, Yang, JO, Lee, KY, Ito, K, Sakakura, C, Li, QL, Kim, HR, Cha, EJ, Lee, YH, Kaneda, A, Ushijima, T, Kim, WJ, Ito, Y, Bae, SC
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