RUNX3 binds the JAG1 gene promoter

Stable Identifier
R-HSA-8878193
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RUNX3 binds the promoter of the JAG1 gene, which encodes a ligand for NOTCH receptors (Nishina et al. 2011).

Literature References
PubMed ID Title Journal Year
21637926 Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling

Nishina, S, Shiraha, H, Nakanishi, Y, Tanaka, S, Matsubara, M, Takaoka, N, Uemura, M, Horiguchi, S, Kataoka, J, Iwamuro, M, Yagi, T, Yamamoto, K

Oncol. Rep. 2011
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