HES1 gene transcription is inhibited by RUNX3

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R-HSA-8878243
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of RUNX3 to the NOTCH1 coactivator complex at the HES1 gene promoter results in repression of HES1 transcription downstream of NOTCH1 signaling (Gao et al. 2010).

Literature References
PubMed ID Title Journal Year
19800882 RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells

Gao, J, Chen, Y, Wu, KC, Liu, J, Zhao, YQ, Pan, YL, Du, R, Zheng, GR, Xiong, YM, Xu, HL, Fan, DM

Exp. Cell Res. 2010
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