Reactome: A Curated Pathway Database

'SLC45A2 [melanosome membrane]' positively regulates 'Tyrosinase oxidises tyrosine to dopaquinone'

Stable Identifier
R-HSA-8878560
Type
PositiveRegulation
Locations in the PathwayBrowser
Summation

The membrane-associated transporter protein SLC45A2 (melanoma antigen AIM1, MATP) shows sequence and structural similarity to sucrose transport proteins yet its actual physiological substrate and role is still unclear. Mutations in SLC45A2 cause misrouting of tyrosinase similar to the cellular phenotype of OCA2 and cause oculocutaneous albinism type 4 (OCA4) (Cullinane et al. 2011).

Literature References
Regulation participants
Regulation type
PositiveRegulation