Reactome | TYRP1 [melanosome membrane]

TYRP1 [melanosome membrane]

Stable Identifier

R-HSA-8878574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

melanosome membrane

Synonyms

5,6-dihydroxyindole-2-carboxylic acid oxidase, TYRP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17643 TYRP1

Gene Names

TYRP1, CAS2, TYRP, TYRRP

Chain

signal peptide:1-24, chain:25-537

Reference Genes

BioGPS Gene:7306 TYRP1

COSMIC (genes):TYRP1 TYRP1

CTD Gene:7306 TYRP1

dbSNP Gene:7306 TYRP1

ENSEMBL:ENSG00000107165 TYRP1

HGNC:12450 TYRP1

KEGG:hsa:7306 TYRP1

Monarch:7306 TYRP1

NCBI Gene:7306 TYRP1

OMIM:115501 TYRP1

UCSC:P17643 TYRP1

Reference Transcript

RefSeq:NM_000550.2 TYRP1

Other Identifiers

11727127_at

11727128_at

17083595

205694_PM_at

205694_at

3162490

3162491

3162492

3162493

3162494

3162495

3162501

3162504

3162505

3162506

3162507

3162508

3162509

3162511

3162512

3162513

36911_at

7306

8154367

A_14_P101680

A_14_P110126

A_23_P94403

A_33_P3399980

GE59755

GO:0003824

GO:0004497

GO:0004503

GO:0005515

GO:0005737

GO:0006091

GO:0006582

GO:0006629

GO:0010008

GO:0016020

GO:0016491

GO:0030154

GO:0030318

GO:0030669

GO:0031410

GO:0032438

GO:0033162

GO:0042438

GO:0042470

GO:0042802

GO:0042803

GO:0043226

GO:0043438

GO:0043473

GO:0046872

GO:0048023

GO:0097708

HMNXSV003038118

ILMN_2054652

PH_hs_0004289

TC09000065.hg

X51420_at

X60955_s_at

g4507756_3p_at

Participates

as an output of

MITF-M-dependent TYRP1 gene expression (Homo sapiens)

Inferred To

tyr-2 [melanosome membrane] (Caenorhabditis elegans)

tyr-5 [melanosome membrane] (Caenorhabditis elegans)

tyrp1b [melanosome membrane] (Danio rerio)

tyrp1 [melanosome membrane] (Xenopus tropicalis)

tyr-4 [melanosome membrane] (Caenorhabditis elegans)

Homologues of TYRP1 [melanosome membrane] (Caenorhabditis elegans)

Homologues of TYRP1 [melanosome membrane] (Dictyostelium discoideum)

Tyrp1 [melanosome membrane] (Rattus norvegicus)

TYRP1 [melanosome membrane] (Bos taurus)

TYRP1 [melanosome membrane] (Caenorhabditis elegans)

TYRP1 [melanosome membrane] (Canis familiaris)

TYRP1 [melanosome membrane] (Dictyostelium discoideum)

TYRP1 [melanosome membrane] (Gallus gallus)

TYRP1 [melanosome membrane] (Mus musculus)

TYRP1 [melanosome membrane] (Sus scrofa)

tyr-6 [melanosome membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENSP00000373570, ENST00000388918

OpenTargets

ENSG00000107165

HPA

ENSG00000107165-TYRP1

PRO

P17643

Pharos - Targets

P17643

GlyGen

P17643

Orphanet

TYRP1

HMDB Protein

HMDBP02139

PDB

5M8S, 5M8R, 5M8Q, 5M8P, 5M8N, 5M8O, 5M8M, 5M8L, 5M8T

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:Q8TF32 ZNF431	1	ZNF431 [nucleoplasm] (R-HSA-1247546)	0.527	2
UniProt:O14908 GIPC1	1	GIPC1 [cytoplasm] (R-HSA-9839329)	0.508	3