SSC5D binds ligands

Stable Identifier
R-HSA-8878603
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SSC5D is a secreted member of group B of the SRCR superfamily. Human SSC5D binds surfaces of whole bacteria and is able to discriminate pathogenic strains from non-pathogenic strains (Bessa Pereira et al. 2016). Mouse Ssc5d (S5D-SRCRB) binds bacterial surface polymers (peptidoglycan, lipopolysaccharide), yeast surface polymers (beta-glucan), and glycoproteins (Galectin-1, Galectin-3, Laminin). Human SSC5D may bind similar ligands but this has not yet been demonstrated. Mouse Ssc5d is expressed in the urogenital tract (Miró-Julià et al. 2014).

Literature References
PubMed ID Title Journal Year
27790215 The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain

Bessa Pereira, C, Bocková, M, Santos, RF, Santos, AM, Martins de Araújo, M, Oliveira, L, Homola, J, Carmo, AM

Front Immunol 2016
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