SSC5D binds ligands

Stable Identifier
R-HSA-8878603
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
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SSC5D binds ligands
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SSC5D is a secreted member of group B of the SRCR superfamily. Human SSC5D binds surfaces of whole bacteria and is able to discriminate pathogenic strains from non-pathogenic strains (Bessa Pereira et al. 2016). Mouse Ssc5d (S5D-SRCRB) binds bacterial surface polymers (peptidoglycan, lipopolysaccharide), yeast surface polymers (beta-glucan), and glycoproteins (Galectin-1, Galectin-3, Laminin). Human SSC5D may bind similar ligands but this has not yet been demonstrated. Mouse Ssc5d is expressed in the urogenital tract (Miró-Julià et al. 2014).

Literature References
PubMed ID Title Journal Year
27790215 The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain

Bessa Pereira, C, Bocková, M, Santos, RF, Santos, AM, Martins de Araújo, M, Oliveira, L, Homola, J, Carmo, AM

Front Immunol 2016
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Ssc5d binds ligands (Mus musculus)
Authored
May, B  (2016-07-11)
Reviewed
Lozano, F  (2017-02-11)
Carmo, AM  (2017-02-11)
Created
May, B  (2016-07-12)
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