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HSPA9 [mitochondrial matrix]
Stable Identifier
R-HSA-8878802
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Stress-70 protein, mitochondrial, GRP75_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Mitochondrial unfolded protein response (UPRmt) (Homo sapiens)
ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70) (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of Stress-70 protein, mitochondrial (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)
HSPA9:HSCB [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)
HSPA9:HSCB [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
Complex III assembly (Homo sapiens)
2Fe-2S is inserted in UQCRFS1 (Homo sapiens)
HSPA9:HSCB [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
LONP1 binds mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
HSPA9 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38646 HSPA9
Gene Names
HSPA9, Stress-70 protein, mitochondrial, GRP75, HSPA9B, mt-HSP70
Chain
transit peptide:1-46, chain:47-679
Reference Genes
BioGPS Gene:3313 HSPA9
COSMIC (genes):HSPA9 HSPA9
CTD Gene:3313 HSPA9
dbSNP Gene:3313 HSPA9
ENSEMBL:ENSG00000113013 HSPA9
ENSEMBL_homo_sapiens_GENE:ENSG00000113013.16 HSPA9
HGNC:5244 HSPA9
KEGG Gene (Homo sapiens):3313 HSPA9
Monarch:3313 HSPA9
NCBI Gene:3313 HSPA9
OMIM:600548 HSPA9
UCSC:P38646 HSPA9
Reference Transcript
RefSeq:NM_004134.6 HSPA9
Other Identifiers
11742920_a_at
11742921_s_at
11750745_a_at
11752595_a_at
11759417_s_at
17000485
200690_PM_at
200690_at
200691_PM_s_at
200691_s_at
200692_PM_s_at
200692_s_at
241840_PM_at
241840_at
2529286
2529292
2529293
2877509
2877510
2877511
2877512
2877513
2877514
2877515
2877516
2877518
2877519
2877521
2877524
2877531
2877533
2877535
2877537
2877538
2877541
2877543
2877546
2877547
2877550
2877551
3313
41509_at
41510_s_at
75250_s_at
8114455
86392_at
A_24_P77676
A_24_P934295
GO:0000166
GO:0001401
GO:0002376
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005743
GO:0005744
GO:0005759
GO:0005925
GO:0006457
GO:0006611
GO:0006790
GO:0006886
GO:0006913
GO:0007005
GO:0007007
GO:0012501
GO:0016226
GO:0016787
GO:0016887
GO:0019899
GO:0030154
GO:0030218
GO:0031072
GO:0031625
GO:0042026
GO:0042645
GO:0043066
GO:0043226
GO:0044183
GO:0045646
GO:0045647
GO:0048856
GO:0051082
GO:0051085
GO:0061024
GO:0070062
GO:0140275
GO:0140657
GO:0140662
GO:1902037
GO:1903707
HMNXSV003015869
Hs.184233.0.A1_3p_at
ILMN_1679209
L11066_at
L15189_s_at
PH_hs_0029370
TC05001832.hg
g12653414_3p_a_at
g4758569_3p_a_at
Participates
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as an output of
Expression of Stress-70 protein, mitochondrial (Homo sapiens)
ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70) (Homo sapiens)
as a component of
HSPA9:HSCB [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
HSPA9 [mitochondrial inner membrane]
HSPA9(1-679) [cytosol]
HSPA9(1-679) [mitochondrial intermembrane space]
HSPA9 [nucleoplasm]
HSPA9 [cytosol]
Inferred To
SSC1 [mitochondrial matrix]
(Saccharomyces cerevisiae)
hspa9 [mitochondrial matrix]
(Xenopus tropicalis)
Hspa9 [mitochondrial matrix]
(Mus musculus)
Hspa9 [mitochondrial matrix]
(Rattus norvegicus)
hsp-6 [mitochondrial matrix]
(Caenorhabditis elegans)
HSPA9 [mitochondrial matrix]
(Bos taurus)
HSPA9 [mitochondrial matrix]
(Canis familiaris)
HSPA9 [mitochondrial matrix]
(Gallus gallus)
HSPA9 [mitochondrial matrix]
(Sus scrofa)
Hsc70-5 [mitochondrial matrix]
(Drosophila melanogaster)
ssc1 [mitochondrial matrix]
(Schizosaccharomyces pombe)
mhsp70 [mitochondrial matrix]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_004125.3
OpenTargets
ENSG00000113013
GeneCards
P38646
HPA
ENSG00000113013-HSPA9
Ensembl
ENST00000297185
,
ENSG00000113013
,
ENSP00000297185
PRO
P38646
Pharos - Targets
P38646
Orphanet
23644
PDB
6PMT
,
6NHK
,
4KBO
,
3N8E
,
6P2U
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.811
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.745
5
UniProt:Q8IWL3 HSCB
5
HSCB [mitochondrial matrix]
(R-HSA-1299438)
HSCB(1-30) [mitochondrial matrix]
(R-HSA-8986120)
HSCB(1-235) [mitochondrial inner membrane]
(R-HSA-1299443)
HSCB [mitochondrial inner membrane]
(R-HSA-1299447)
HSCB(1-235) [mitochondrial intermembrane space]
(R-HSA-1299456)
0.742
14
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
23
UniProt:Q9HAV7 GRPEL1
1
GRPEL1 [mitochondrial inner membrane]
(R-HSA-1252062)
0.669
5
UniProt:P21912 SDHB
2
SDHB [mitochondrial matrix]
(R-HSA-9854983)
SDHB [mitochondrial inner membrane]
(R-HSA-70985)
0.662
10
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.637
11
UniProt:Q9H6A0 DENND2D
1
DENND2D [cytosol]
(R-HSA-8876071)
0.623
3
UniProt:P13693 TCTP
0.567
4
UniProt:A4D2J0 A4D2J0
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:P53051 MALX3
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.527
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.527
2
UniProt:Q99592 ZBT18
0.527
2
UniProt:Q5SXM8 DNLZ
0.527
2
UniProt:O75165 DNAJC13
3
DNAJC13 [secretory granule membrane]
(R-HSA-6800951)
DNAJC13 [plasma membrane]
(R-HSA-6806255)
DNAJC13 [azurophil granule membrane]
(R-HSA-6799140)
0.527
2
UniProt:Q96NG3 ODAD4
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
5
UniProt:Q8ND83 SLAI1
0.527
2
UniProt:Q92733 PRCC
1
PRCC [nucleoplasm]
(R-HSA-8867896)
0.527
2
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.527
3
UniProt:Q8WX92 NELFB
3
NELFB [nucleoplasm]
(R-HSA-112427)
NELFB [cytosol]
(R-HSA-9603526)
NELFB [mitochondrial outer membrane]
(R-HSA-9603553)
0.524
2
UniProt:Q99650 OSMR
1
OSMR [plasma membrane]
(R-HSA-448654)
0.499
4
UniProt:Q9H1K1 ISCU
1
ISCU [cytosol]
(R-HSA-9771680)
0.499
3
UniProt:Q8TDU6 GPBAR1
1
GPBAR1 [plasma membrane]
(R-HSA-444640)
0.463
3
UniProt:Q8N0X7 SPART
0.462
2
UniProt:Q00005 2ABB
0.462
2
UniProt:Q5U5X0 LYRM7
1
LYRM7 [mitochondrial matrix]
(R-HSA-9866252)
0.462
2
UniProt:P47985 UQCRFS1
3
UQCRFS1(1-274) [mitochondrial inner membrane]
(R-HSA-9906005)
UQCRFS1(1-274) [mitochondrial matrix]
(R-HSA-9906006)
UQCRFS1(79-274) [mitochondrial inner membrane]
(R-HSA-164278)
0.462
4
UniProt:A6NFY7 SDHAF1
1
SDHAF1 [mitochondrial matrix]
(R-HSA-9854988)
0.462
2
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