B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer

Stable Identifier
R-HSA-8878914
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Globosides are a type of glycosphingolipid with more than one sugar as the side chain of ceramide, usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. They are components of cellular membranes, especially of the kidneys, red blood cells, blood serum, liver and spleen. Globoside synthesis (and therefore accummulation) increases in pathological conditions including neurodegenerative disorders, immune diseases and cancer. UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (B3GALNT1, B3GALT3) is a Golgi membrane-associated protein that can add N-acetylgalactosamine (GalNAc) to globotriaosylceramide (Gb3Cer) to form Gb4Cer (Okajima et al. 2000, Amado et al. 1998).

Literature References
PubMed ID Title Journal Year
9582303 A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family

Amado, M, Almeida, R, Carneiro, F, Levery, SB, Holmes, EH, Nomoto, M, Hollingsworth, MA, Hassan, H, Schwientek, T, Nielsen, PA, Bennett, EP, Clausen, H

J Biol Chem 1998
10993897 Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase

Okajima, T, Nakamura, Y, Uchikawa, M, Haslam, DB, Numata, SI, Furukawa, K, Furukawa, K, Urano, T

J. Biol. Chem. 2000
Participants
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Catalyst Activity
Catalyst Activity
Title
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity of B3GALNT1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created