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PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Stable Identifier
R-HSA-888580
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
Synonyms
Glutamate decarboxylase 1, DCE1_HUMAN, GAD67
Locations in the PathwayBrowser for interactor UniProt:Q13188
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates transcription of genes involved in GABA signaling (Homo sapiens)
GAD1 gene expression is stimulated by MECP2 (Homo sapiens)
PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99259 GAD1
Gene Names
GAD1, GAD, GAD67
Chain
chain:1-594
Reference Genes
BioGPS Gene:2571 GAD1
COSMIC (genes):GAD1 GAD1
CTD Gene:2571 GAD1
dbSNP Gene:2571 GAD1
ENSEMBL:ENSG00000128683 GAD1
HGNC:4092 GAD1
KEGG Gene (Homo sapiens):2571 GAD1
Monarch:2571 GAD1
NCBI Gene:2571 GAD1
OMIM:605363 GAD1
UCSC:Q99259 GAD1
Reference Transcript
RefSeq:XM_017003758.1 GAD1
RefSeq:NM_000817.2 GAD1
RefSeq:XM_011510922.1 GAD1
RefSeq:XM_017003756.1 GAD1
RefSeq:NM_013445.3 GAD1
RefSeq:XM_005246444.2 GAD1
Other Identifiers
0000130022
0000130433
0000130494
11725618_a_at
11725619_a_at
11729094_a_at
16887492
205278_at
206669_at
206670_s_at
2514973
2514974
2514975
2514976
2514977
2514978
2514979
2514980
2514981
2514982
2514983
2514984
2514989
2515001
2515003
2515013
2515019
2515020
2515021
2515023
2515027
2515029
2515030
2515033
2515035
2515036
2515038
2515043
2515044
2515045
2515046
2515047
2515048
2515049
2571
37183_at
8046283
84447_at
A_14_P101836
A_23_P209578
A_23_P374689
A_24_P319711
A_33_P3365142
GE58098
GO:0003674
GO:0003824
GO:0004351
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0005938
GO:0006464
GO:0006520
GO:0006538
GO:0006540
GO:0006810
GO:0007267
GO:0007268
GO:0007269
GO:0008150
GO:0009056
GO:0009058
GO:0009449
GO:0012506
GO:0016595
GO:0016829
GO:0016831
GO:0018352
GO:0019752
GO:0030170
GO:0030424
GO:0031410
GO:0035176
GO:0035641
GO:0042136
GO:0042493
GO:0043167
GO:0043226
GO:0043679
GO:0044281
GO:0044306
GO:0044877
GO:0045202
GO:0047485
GO:0048786
GO:0060077
GO:0061202
ILMN_1660973
ILMN_1712731
ILMN_1812859
ILMN_2292646
M81883_at
PH_hs_0025119
TC02001016.hg
g4503872_3p_at
g7305076_3p_a_at
g7305076_3p_at
Participant Of
output
GAD1 gene expression is stimulated by MECP2
hasComponent
PXLP-GAD1:PXLP-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
PXLP-K405-GAD1 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Other forms of this molecule
PXLP-K405-GAD1 [plasma membrane]
Inferred To
Gad1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Drosophila melanogaster)
Gad1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Mus musculus)
Gad1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Rattus norvegicus)
ppp3cb [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Xenopus tropicalis)
b [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Drosophila melanogaster)
unc-25 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)
GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Bos taurus)
GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Sus scrofa)
gad1a [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Danio rerio)
Homologues of PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Drosophila melanogaster)
GAD67 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Gallus gallus)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 405
Coordinate
405
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
XP_005246501.1
,
NP_038473.2
,
NP_000808.2
,
XP_016859245.1
,
XP_016859247.1
,
XP_011509224.1
OpenTargets
ENSG00000128683
HPA
ENSG00000128683-GAD1
GeneCards
Q99259
Ensembl
ENST00000375272
,
ENSP00000341167
,
ENSP00000486612
,
ENSP00000364421
,
ENSG00000128683
,
ENST00000625689
,
ENST00000493875
,
ENST00000358196
,
ENST00000344257
,
ENSP00000434696
,
ENSP00000350928
PRO
Q99259
Orphanet
20284
HMDB Protein
HMDBP00703
PDB
3VP6
,
2OKJ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46952 HAAO
1
HAAO [cytosol]
(R-HSA-71085)
0.83
8
UniProt:Q96DZ9-2 CMTM5
0.718
6
UniProt:Q969L2 MAL2
0.718
6
UniProt:Q6RW13-2 AGTRAP
0.718
6
UniProt:Q96DZ9 CKLF5
0.666
4
UniProt:Q6RW13 AGTRAP
2
AGTRAP-BRAF fusion [cytosol]
(R-HSA-6802262)
p-AGTRAP-BRAF fusion [cytosol]
(R-HSA-6802511)
0.556
3
UniProt:P38635 HIS9
0.556
3
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
STK3(1-491) [cytosol]
(R-HSA-2028280)
0.556
3
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