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WDR61 [cytosol]
Stable Identifier
R-HSA-8931534
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WD repeat-containing protein 61, WDR61_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
mRNA decay by 3' to 5' exoribonuclease (Homo sapiens)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)
Exosome:SKI complex [cytosol] (Homo sapiens)
SKI complex [cytosol] (Homo sapiens)
WDR61 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZS3 SKIC8
Gene Names
SKIC8, WDR61
Chain
chain:1-305, initiator methionine:, chain:2-305
Reference Genes
BioGPS Gene:80349 SKIC8
COSMIC (genes):WDR61 SKIC8
CTD Gene:80349 SKIC8
dbSNP Gene:80349 SKIC8
ENSEMBL:ENSG00000140395 WDR61
HGNC:30300 SKIC8
KEGG:hsa:80349 SKIC8
Monarch:80349 SKIC8
NCBI Gene:80349 SKIC8
OMIM:609540 SKIC8
UCSC:Q9GZS3 SKIC8
Reference Transcript
RefSeq:XM_011522094.1 SKIC8
RefSeq:NM_025234.2 SKIC8
RefSeq:NM_001303248.1 SKIC8
RefSeq:NM_001303247.1 SKIC8
Other Identifiers
11757639_a_at
11761627_a_at
16812142
221531_PM_at
221531_at
221532_PM_s_at
221532_s_at
232075_PM_at
232075_at
237208_PM_at
237208_at
3634589
3634590
3634594
3634595
3634596
3634597
3634598
3634599
3634600
3634601
3634602
3634603
3634604
3634605
3634606
3634607
3634608
3634609
3634610
3634611
3634612
3634613
3634614
3634616
3634617
3634618
3634619
3634620
3634621
3634622
3634624
3634625
3634626
36431_at
73479_at
7990700
80349
90320_at
A_23_P49021
GE56402
GE79470
GE84923
GO:0000791
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006368
GO:0016055
GO:0016071
GO:0016593
GO:0043226
GO:0045638
GO:0055087
GO:0070478
GO:0072344
HMNXSV003009479
Hs.125457.0.A1_3p_at
Hs.167456.0.S1_3p_at
Hs.306765.0.S1_3p_at
ILMN_1665887
PH_hs_0022380
TC15001703.hg
g11139241_3p_at
g11139241_3p_s_at
Participates
as a component of
SKI complex [cytosol] (Homo sapiens)
Other forms of this molecule
WDR61 [nucleoplasm]
Inferred To
SKIC8 [cytosol]
(Bos taurus)
SKIC8 [cytosol]
(Canis familiaris)
SKIC8 [cytosol]
(Sus scrofa)
Skic8 [cytosol]
(Mus musculus)
Skic8 [cytosol]
(Rattus norvegicus)
SKI8 [cytosol]
(Saccharomyces cerevisiae)
WDR61 [cytosol]
(Caenorhabditis elegans)
WDR61 [cytosol]
(Gallus gallus)
skic8 [cytosol]
(Dictyostelium discoideum)
skic8 [cytosol]
(Xenopus tropicalis)
Dmel\CG3909 [cytosol]
(Drosophila melanogaster)
rec14 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
XP_011520396.1
,
NP_079510.1
,
NP_001290177.1
,
NP_001290176.1
OpenTargets
ENSG00000140395
ENSEMBL
ENST00000558311
,
ENSP00000267973
,
ENSP00000453801
,
ENST00000267973
HPA
ENSG00000140395-SKIC8
PRO
Q9GZS3
Pharos - Targets
Q9GZS3
GlyGen
Q9GZS3
PDB
7UND
,
6TED
,
7QDZ
,
7OPC
,
7OOP
,
7QDS
,
7UNC
,
7QDY
,
3OW8
,
7QDR
,
6GMH
,
7OPD
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.905
13
UniProt:Q8WVC0 LEO1
1
LEO1 [nucleoplasm]
(R-HSA-3322361)
0.725
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
22
UniProt:P02545-2 LMNA
5
LMNA-2 [cytosol]
(R-HSA-2995387)
Lamin C [nucleoplasm]
(R-HSA-264872)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
LMNA-2 [nuclear envelope]
(R-HSA-912378)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q16143 SNCB
1
SNCB [cytosol]
(R-HSA-5660390)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
NOS3 [cytosol]
(R-HSA-202114)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
0.556
3
UniProt:Q16595 FXN
6
FXN(81-210) [mitochondrial matrix]
(R-HSA-1362390)
FXN(1-41) [mitochondrial matrix]
(R-HSA-8986117)
FXN(1-210) [mitochondrial inner membrane]
(R-HSA-1299444)
FXN(42-210) [mitochondrial inner membrane]
(R-HSA-1299454)
FXN(1-210) [mitochondrial intermembrane space]
(R-HSA-1299451)
FXN(42-210) [mitochondrial matrix]
(R-HSA-1299445)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.556
3
UniProt:Q99497 PARK7
7
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
PARK7 [nucleoplasm]
(R-HSA-3900141)
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
0.556
3
UniProt:P51149 RAB7A
7
RAB7A [secretory granule membrane]
(R-HSA-6804969)
RAB7A [plasma membrane]
(R-HSA-6804990)
RAB7A [cytosol]
(R-HSA-8870415)
RAB7A [phagocytic vesicle membrane]
(R-HSA-9636586)
RAB7A [lysosomal membrane]
(R-HSA-2213231)
GGC-RAB7A [cytosol]
(R-HSA-8870438)
GGC-RAB7A [lysosomal membrane]
(R-HSA-8877454)
0.556
3
UniProt:O75533 SF3B1
1
SF3B1 [nucleoplasm]
(R-HSA-71968)
0.527
2
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