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GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8931656
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Icon
Locations in the PathwayBrowser for interactor UniProt:P20036 HLA-DPA1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
DAG1 glycosylations (Homo sapiens)
DAG1 core M3 glycosylations (Homo sapiens)
B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (Homo sapiens)
POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14118 DAG1
Gene Names
DAG1
Chain
signal peptide:1-29, chain:30-653, chain:654-895
Reference Genes
COSMIC (genes):DAG1 DAG1
dbSNP Gene:1605 DAG1
ENSEMBL:ENSG00000173402 DAG1
Participates
as an output of
B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)
as an input of
POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)
Other forms of this molecule
DAG1(654-895) [plasma membrane]
DAG1(30-653) [extracellular region]
DAG1(30-653) [cytosol]
DAG1(30-653) [endoplasmic reticulum lumen]
Man-DAG1 [endoplasmic reticulum lumen]
DAG1 [endoplasmic reticulum membrane]
DAG1(654-895) [endoplasmic reticulum membrane]
Core M1,3-DAG1 [Golgi lumen]
Core M1,2,3-DAG1 [Golgi lumen]
Core M3-DAG1 [Golgi lumen]
GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]
GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
Xyl-GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
Matriglycan-DAG1 [Golgi lumen]
3S-Matriglycan-DAG1 [Golgi lumen]
Man-DAG1 [Golgi lumen]
GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region]
DAG1(654-895) [Golgi membrane]
Inferred To
DAG1 [endoplasmic reticulum lumen]
(Bos taurus)
DAG1 [endoplasmic reticulum lumen]
(Canis familiaris)
DAG1 [endoplasmic reticulum lumen]
(Sus scrofa)
Dag1 [endoplasmic reticulum lumen]
(Mus musculus)
Dag1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
Dg [endoplasmic reticulum lumen]
(Drosophila melanogaster)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(Gallus gallus)
dgn-1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
dag1 [endoplasmic reticulum lumen]
(Danio rerio)
dag1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Modified Residues
Name
O-mannosyl-L-threonine (N-acetyl-β-D-galactosaminyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→4)-α-D-mannosyl-L-threonine residue) at 367
Coordinate
367
Modification
N-acetyl-β-D-galactosaminyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→4)-α-D-mannosyl-L-threonine residue
PsiMod Name
O-mannosyl-L-threonine
PsiMod Definition
a protein modification that effectively forms a O3-mannosylthreonine
Name
O-mannosyl-L-threonine (O-(α-D-mannosyl)-L-threonine residue) at 423
Coordinate
423
Modification
O-(α-D-mannosyl)-L-threonine residue
PsiMod Name
O-mannosyl-L-threonine
PsiMod Definition
a protein modification that effectively forms a O3-mannosylthreonine
Name
O-mannosyl-L-threonine (O-(α-D-mannosyl)-L-threonine residue) at 481
Coordinate
481
Modification
O-(α-D-mannosyl)-L-threonine residue
PsiMod Name
O-mannosyl-L-threonine
PsiMod Definition
a protein modification that effectively forms a O3-mannosylthreonine
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14118 DAG1
20
DAG1(654-895) [plasma membrane]
(R-HSA-2328154)
DAG1(30-653) [extracellular region]
(R-HSA-2328152)
DAG1(30-653) [cytosol]
(R-HSA-5615641)
DAG1(30-653) [endoplasmic reticulum lumen]
(R-HSA-8931890)
Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-5615647)
DAG1 [endoplasmic reticulum membrane]
(R-HSA-9913254)
DAG1(654-895) [endoplasmic reticulum membrane]
(R-HSA-9913257)
Core M1,3-DAG1 [Golgi lumen]
(R-HSA-5617087)
Core M1,2,3-DAG1 [Golgi lumen]
(R-HSA-8932424)
Core M3-DAG1 [Golgi lumen]
(R-HSA-9940750)
GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931659)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931656)
GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931673)
RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940668)
Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940723)
RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940763)
GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940727)
Xyl-GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940697)
Matriglycan-DAG1 [Golgi lumen]
(R-HSA-9940706)
3S-Matriglycan-DAG1 [Golgi lumen]
(R-HSA-9940731)
0.558
2
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.527
2
UniProt:P32971 TNFSF8
1
TNFSF8 [plasma membrane]
(R-HSA-5667148)
0.527
3
UniProt:O00214 LEG8
0.527
2
UniProt:Q9NU53 GINM1
0.527
2
UniProt:Q9Y5G4 PCDG9
0.527
2
UniProt:Q8WXA8 HTR3C
1
HTR3C [plasma membrane]
(R-HSA-975312)
0.527
2
UniProt:O95302 FKBP9
1
FKBP9 [cytosol]
(R-HSA-391306)
0.527
2
UniProt:Q9Y5F2 PCDBB
0.527
2
UniProt:Q96GX1 TCTN2
1
TCTN2 [ciliary membrane]
(R-HSA-5626661)
0.527
2
UniProt:P20036 HLA-DPA1
9
HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane]
(R-HSA-197586)
HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]
(R-HSA-2130639)
HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane]
(R-HSA-2130435)
HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130485)
HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane]
(R-HSA-2130648)
HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]
(R-HSA-2130337)
HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane]
(R-HSA-2214387)
HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130739)
HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130667)
0.527
2
UniProt:P46939 UTRN
1
UTRN [cytosol]
(R-HSA-5216039)
0.527
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.527
2
UniProt:Q9UK22 FBXO2
1
FBXO2 [cytosol]
(R-HSA-976044)
0.527
2
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.462
2
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