Reactome | DAG1(30-653) [endoplasmic reticulum lumen]

DAG1(30-653) [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8931890

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Alpha-dystroglycan, Dystroglycan alpha, DAG1_HUMAN, DAG1

Locations in the PathwayBrowser for interactor UniProt:P20036 HLA-DPA1

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External Reference Information

External Reference

UniProt:Q14118 DAG1

Gene Names

DAG1

Chain

signal peptide:1-29, chain:30-653, chain:654-895

Reference Genes

BioGPS Gene:1605 DAG1

COSMIC (genes):DAG1 DAG1

CTD Gene:1605 DAG1

dbSNP Gene:1605 DAG1

ENSEMBL:ENSG00000173402 DAG1

ENSEMBL_homo_sapiens_GENE:ENSG00000173402.13 DAG1

HGNC:2666 DAG1

KEGG Gene (Homo sapiens):1605 DAG1

Monarch:1605 DAG1

NCBI Gene:1605 DAG1

OMIM:128239 DAG1

UCSC:Q14118 DAG1

Reference Transcript

Other Identifiers

11715548_a_at

11715549_at

11715550_at

11746796_a_at

11757880_s_at

1605

16940705

205417_PM_s_at

205417_s_at

212128_PM_s_at

212128_s_at

2622123

2622124

2622125

2622126

2622127

2622128

2622129

2622132

2622133

2622134

2622135

2622137

2622138

2622139

2622140

2622141

2622142

2622143

36989_at

8079753

A_14_P138724

A_23_P212579

A_24_P225961

GE57661

GO:0001618

GO:0001954

GO:0002009

GO:0002011

GO:0002162

GO:0003007

GO:0003012

GO:0003779

GO:0005198

GO:0005509

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005912

GO:0005925

GO:0006509

GO:0007010

GO:0007155

GO:0007411

GO:0007507

GO:0008092

GO:0008307

GO:0009897

GO:0009986

GO:0010470

GO:0010717

GO:0014037

GO:0014044

GO:0014850

GO:0014894

GO:0015031

GO:0015631

GO:0016010

GO:0016011

GO:0016020

GO:0016203

GO:0016323

GO:0016340

GO:0016476

GO:0017166

GO:0021675

GO:0021682

GO:0022011

GO:0023052

GO:0030027

GO:0030154

GO:0030175

GO:0030198

GO:0030312

GO:0030336

GO:0031012

GO:0031103

GO:0031643

GO:0033268

GO:0034330

GO:0034399

GO:0034453

GO:0042060

GO:0042169

GO:0042383

GO:0043034

GO:0043226

GO:0043231

GO:0043236

GO:0043237

GO:0043403

GO:0043409

GO:0043434

GO:0044853

GO:0044877

GO:0045121

GO:0045202

GO:0045211

GO:0046718

GO:0048167

GO:0048714

GO:0048856

GO:0048870

GO:0050807

GO:0051393

GO:0051898

GO:0060055

GO:0060441

GO:0060445

GO:0062023

GO:0070062

GO:0070938

GO:0071260

GO:0071397

GO:0071407

GO:0071679

GO:0071711

GO:0098684

GO:0098696

GO:0098794

GO:0098942

GO:0098978

GO:0098982

GO:0099524

GO:1904261

HMNXSV003040329

Hs.76111.1.A1_3p_a_at

ILMN_1658425

ILMN_1663963

L19711_at

PH_hs_0004391

TC03000295.hg

g4758115_3p_a_at

Participates

as an input of

POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Homo sapiens)

Other forms of this molecule

GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]

GlcNAc,1,2-Man-DAG1 [Golgi lumen]

Man-DAG1 [Golgi lumen]

GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]

GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]

Man-DAG1 [endoplasmic reticulum lumen]

DAG1(30-653) [cytosol]

DAG1(30-653) [extracellular region]

DAG1(654-895) [plasma membrane]

Inferred To

DAG1 [endoplasmic reticulum lumen] (Bos taurus)

DAG1 [endoplasmic reticulum lumen] (Canis familiaris)

DAG1 [endoplasmic reticulum lumen] (Sus scrofa)

Dag1 [endoplasmic reticulum lumen] (Mus musculus)

Dag1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Dg [endoplasmic reticulum lumen] (Drosophila melanogaster)

DAG1(30-653) [endoplasmic reticulum lumen] (Gallus gallus)

dgn-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

dag1 [endoplasmic reticulum lumen] (Danio rerio)

dag1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001171111.1, NP_001171105.1, NP_001171114.1, NP_001159400.2, NP_001171108.1, NP_001171106.1, NP_001171110.1, NP_001171112.1, NP_001171109.1, NP_001171107.1, NP_004384.4, NP_001171113.1, NP_001171115.1

OpenTargets

ENSG00000173402

GeneCards

Q14118

HPA

ENSG00000173402-DAG1

Ensembl

ENST00000673708, ENSP00000312435, ENSP00000513218, ENST00000452060, ENSP00000401805, ENST00000469139, ENSG00000173402, ENST00000466701, ENSP00000401382, ENST00000452317, ENSP00000387859, ENSP00000513216, ENSP00000513217, ENST00000431960, ENST00000496474, ENST00000435508, ENST00000430636, ENST00000428779, ENSP00000405859, ENSP00000412067, ENST00000697271, ENSP00000415321, ENSP00000410145, ENSP00000501140, ENST00000418588, ENSP00000388833, ENSP00000501165, ENST00000421560, ENST00000308775

PRO

Q14118

Pharos - Targets

Q14118

Orphanet

20457

PDB

6JJY, 2MK7, 5GGP, 7E9K, 7E9L, 5LLK, 1EG4

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14118 DAG1	10	GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(654-895) [plasma membrane] (R-HSA-2328154)	0.558	2
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.527	2
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.527	2
UniProt:O00214 LEG8			0.527	2
UniProt:Q9NU53 GINM1			0.527	2
UniProt:Q8WXA8 HTR3C	1	HTR3C [plasma membrane] (R-HSA-975312)	0.527	2
UniProt:O95302 FKBP9	1	FKBP9 [cytosol] (R-HSA-391306)	0.527	2
UniProt:Q9Y5F2 PCDBB			0.527	2
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.527	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586)	0.527	2
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.527	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.527	3
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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