N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A

Stable Identifier
R-HSA-8931974
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A
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Eukaryotic elongation factor 1A (EEF1A) is an essential, highly methylated protein that facilitates translational elongation by delivering aminoacyl-tRNAs to ribosomes. EEF1AKMT1 (N6AMT2) trimethylates EEF1A at Lys-79, a high-stoichiometry N-terminal site that is conserved from yeast to humans (Hamey et al. 2016).
Literature References
PubMed ID Title Journal Year
26545399 Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human

Hamey, JJ, Winter, DL, Yagoub, D, Overall, CM, Hart-Smith, G, Wilkins, MR

Mol. Cell Proteomics 2016
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Catalyst Activity

protein-lysine N-methyltransferase activity of N6AMT2 [cytosol]

Physical Entity
N6AMT2 [cytosol] (Homo sapiens)
Activity
protein-lysine N-methyltransferase activity (GO:0016279)
Orthologous Events
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Danio rerio)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Mus musculus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Sus scrofa)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)
Authored
Jupe, S  (2016-06-16)
Reviewed
Falnes, PØ  (2016-10-10)
Created
Jupe, S  (2016-07-20)
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