RUNX1 regulates estrogen receptor mediated transcription

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R-HSA-8931987
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Pathway
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Homo sapiens
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The RUNX1:CBFB complex can associate with the activated estrogen receptor alpha (ESR1) through direct interaction between RUNX1 and ESR1. The RUNX1:CBFB complex is thus involved in transcriptional regulation of estrogen responsive genes, including GPAM, KCTD6 and AXIN1 (Stender et al. 2010). High GPAM expression correlates with better overall survival in breast cancer (Brockmoller et al. 2012).

Literature References
PubMed ID Title Journal Year
20547749 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Stender, JD, Kim, K, Charn, TH, Komm, B, Chang, KC, Kraus, WL, Benner, C, Glass, CK, Katzenellenbogen, BS

Mol. Cell. Biol. 2010
22070544 Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling

Brockmöller, SF, Bucher, E, Müller, BM, Budczies, J, Hilvo, M, Griffin, JL, Orešič, M, Kallioniemi, O, Iljin, K, Loibl, S, Darb-Esfahani, S, Sinn, BV, Klauschen, F, Prinzler, J, Bangemann, N, Ismaeel, F, Fiehn, O, Dietel, M, Denkert, C

J. Proteome Res. 2012
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