GPAM gene expression is stimulated by RUNX1 and ESR1

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R-HSA-8932020
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Reaction [omitted]
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Homo sapiens
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GPAM gene expression is cooperatively stimulated by RUNX1 and ESR1, which form a complex and bind the GPAM gene enhancer (Stender et al. 2010). GPAM encodes a glycerol-3-phosphate acyltransferase whose high expression correlates with better overall survival in breast cancer (Brockmoller et al. 2012).

Literature References
PubMed ID Title Journal Year
20547749 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Stender, JD, Kim, K, Charn, TH, Komm, B, Chang, KC, Kraus, WL, Benner, C, Glass, CK, Katzenellenbogen, BS

Mol. Cell. Biol. 2010
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