AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1

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R-HSA-8932076
Type
Reaction [omitted]
Species
Homo sapiens
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Transciption of the AXIN1 gene, which encodes a component of the beta-catenin (CTNNB1) destruction complex, is inhibited by binding of the activated estrogen receptor alpha (ESR1) to estrogen response elements in the second intron of AXIN1 (Chimge et al. 2016).
The AXIN1 gene expression is stimulated by cooperative binding of RUNX1 and estrogen receptor alpha (ESR1) to adjacent RUNX1 binding sites and estrogen response elements in the second intron of AXIN1 (Chimge et al. 2016).

Literature References
PubMed ID Title Journal Year
26916619 RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

Chimge, NO, Little, GH, Baniwal, SK, Adisetiyo, H, Xie, Y, Zhang, T, O'Laughlin, A, Liu, ZY, Ulrich, P, Martin, A, Mhawech-Fauceglia, P, Ellis, MJ, Tripathy, D, Groshen, S, Liang, C, Li, Z, Schones, DE, Frenkel, B

Nat Commun 2016
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