RUNX1 and ESR1 bind the AXIN1 gene

Stable Identifier
R-HSA-8932084
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RUNX1 and ESR1, which are known to form a complex (Stender et al. 2010), cooperatively bind to adjacent Runx binding sites and estrogen response elements, respectively, in the second intron of the AXIN1 gene (Chimge et al. 2016).

Literature References
PubMed ID Title Journal Year
26916619 RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

Chimge, NO, Little, GH, Baniwal, SK, Adisetiyo, H, Xie, Y, Zhang, T, O'Laughlin, A, Liu, ZY, Ulrich, P, Martin, A, Mhawech-Fauceglia, P, Ellis, MJ, Tripathy, D, Groshen, S, Liang, C, Li, Z, Schones, DE, Frenkel, B

Nat Commun 2016
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