EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2

Stable Identifier
R-HSA-8932243
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2
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Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT) catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on Lys-525.
Literature References
PubMed ID Title Journal Year
25231979 Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)

Davydova, E, Ho, AY, Malecki, J, Moen, A, Enserink, JM, Jakobsson, ME, Loenarz, C, Falnes, PØ

J. Biol. Chem. 2014
Participants
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Output
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as an event of
Catalyst Activity

protein-lysine N-methyltransferase activity of EEF2KMT [cytosol]

Physical Entity
EEF2KMT [cytosol] (Homo sapiens)
Activity
protein-lysine N-methyltransferase activity (GO:0016279)
Orthologous Events
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Caenorhabditis elegans)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Dictyostelium discoideum)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Schizosaccharomyces pombe)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)
EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)
Authored
Jupe, S  (2016-06-16)
Reviewed
Falnes, PØ  (2016-10-10)
Created
Jupe, S  (2016-07-22)
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