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p-S,T-NFE2L2 [cytosol]
Stable Identifier
R-HSA-8932311
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:P78545 ELF3
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
CK2 phosphorylates NFE2L2 (Homo sapiens)
p-S,T-NFE2L2 [cytosol] (Homo sapiens)
EIF2AK3 phosphorylates NFE2L2 (Homo sapiens)
p-S,T-NFE2L2 [cytosol] (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
PRKAA2 regulated nuclear export of NFE2L2 (Homo sapiens)
p-S,T-NFE2L2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16236 NFE2L2
Gene Names
NFE2L2, NRF2
Chain
chain:1-605
Reference Genes
BioGPS Gene:4780 NFE2L2
COSMIC (genes):NFE2L2 NFE2L2
CTD Gene:4780 NFE2L2
dbSNP Gene:4780 NFE2L2
ENSEMBL:ENSG00000116044 NFE2L2
HGNC:7782 NFE2L2
KEGG:hsa:4780 NFE2L2
Monarch:4780 NFE2L2
NCBI Gene:4780 NFE2L2
OMIM:600492 NFE2L2
UCSC:Q16236 NFE2L2
Reference Transcript
RefSeq:NM_001313900.1 NFE2L2
RefSeq:NM_001313901.1 NFE2L2
RefSeq:NM_001145413.3 NFE2L2
RefSeq:NM_001145412.3 NFE2L2
RefSeq:NM_006164.4 NFE2L2
Other Identifiers
11739057_a_at
11743380_s_at
1567013_PM_at
1567013_at
16905475
201146_PM_at
201146_at
207688_PM_s_at
207688_s_at
2588820
2588822
2588824
2588825
2588826
2588828
2588829
2588831
2588832
2588833
2588834
2588835
2588836
2588837
2588838
2588839
2588840
2588841
2588842
2588843
2588844
2588845
2588846
2588847
2588863
2588864
2588865
2588866
2588867
2588868
2588870
2588871
2588890
2588896
2588905
2588906
2588908
2588909
2588910
2588913
2588915
2588916
2588924
2654549
4024236
4780
8056977
82873_at
853_at
91941_at
A_19_P00315584
A_19_P00319717
A_23_P5761
A_24_P400172
A_32_P134772
A_33_P3225600
GE81603
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001221
GO:0001228
GO:0002931
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0006954
GO:0006979
GO:0009410
GO:0010468
GO:0010499
GO:0010628
GO:0010667
GO:0010976
GO:0016567
GO:0016592
GO:0019904
GO:0030163
GO:0030194
GO:0030968
GO:0031625
GO:0032993
GO:0034599
GO:0034976
GO:0036499
GO:0042149
GO:0043161
GO:0043226
GO:0043536
GO:0043565
GO:0045088
GO:0045454
GO:0045766
GO:0045893
GO:0045944
GO:0045995
GO:0046223
GO:0046326
GO:0060090
GO:0061431
GO:0061629
GO:0070301
GO:0071280
GO:0071356
GO:0071456
GO:0071466
GO:0071498
GO:0071499
GO:0080090
GO:0090575
GO:0098754
GO:0110076
GO:0140110
GO:0140467
GO:0140693
GO:1900038
GO:1900407
GO:1902037
GO:1902176
GO:1903788
GO:1904294
GO:1904385
GO:1904753
GO:2000060
GO:2000121
GO:2000352
GO:2000379
HMNXSV003047979
ILMN_1696318
ILMN_1790909
PH_hs_0009358
S74017_at
TC02004721.hg
TC02005045.hg
TC03002972.hg
g5031794_3p_at
g5453775_3p_at
p26100
p9452
Participates
as an output of
EIF2AK3 phosphorylates NFE2L2 (Homo sapiens)
PRKAA2 regulated nuclear export of NFE2L2 (Homo sapiens)
CK2 phosphorylates NFE2L2 (Homo sapiens)
as a candidate of
p-NFE2L2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S40-NFE2L2 [nucleoplasm]
p-S,T-NFE2L2 [nucleoplasm]
p-S40-NFE2L2 [cytosol]
NFE2L2 [cytosol]
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
p-S40-18 AcK-NFE2L2 [nucleoplasm]
ub-NFE2L2 [cytosol]
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
p-S344, S347,T-NFE2L2 [nucleoplasm]
p-S40, S344, S347- NFE2L2 [nucleoplasm]
p-S,T,S558-NFE2L2 [nucleoplasm]
Inferred To
phospho-skn-1 [cytosol]
(Caenorhabditis elegans)
phospho-nfe2l2 [cytosol]
(Xenopus tropicalis)
Homologues of p-S,T-NFE2L2 [cytosol]
(Caenorhabditis elegans)
phospho-NFE2L2 [cytosol]
(Bos taurus)
phospho-NFE2L2 [cytosol]
(Canis familiaris)
phospho-NFE2L2 [cytosol]
(Sus scrofa)
phospho-cnc [cytosol]
(Drosophila melanogaster)
phospho-p-S,T-NFE2L2 [cytosol]
(Gallus gallus)
phospho-sknr-1 [cytosol]
(Caenorhabditis elegans)
phospho-Nfe2l2 [cytosol]
(Mus musculus)
phospho-Nfe2l2 [cytosol]
(Rattus norvegicus)
phospho-nfe2l2a [cytosol]
(Danio rerio)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001138884.1
,
NP_001138885.1
,
NP_006155.2
,
NP_001300829.1
,
NP_001300830.1
Guide to Pharmacology - Targets
3057
OpenTargets
ENSG00000116044
ENSEMBL
ENST00000446151
,
ENSP00000514370
,
ENST00000699330
,
ENST00000699434
,
ENST00000421929
,
ENST00000464747
,
ENSP00000400073
,
ENST00000397063
,
ENST00000397062
,
ENST00000699351
,
ENSP00000411575
,
ENSP00000514318
,
ENST00000448782
,
ENSP00000467401
,
ENSP00000380253
,
ENSP00000380252
,
ENST00000699409
,
ENST00000699408
,
ENST00000699328
,
ENSP00000412191
,
ENST00000699343
,
ENSP00000514386
,
ENSP00000514303
,
ENSP00000514369
,
ENSP00000514325
,
ENSP00000514304
ZINC - Substances
NF2L2_HUMAN
ZINC - Biogenic
NF2L2_HUMAN
ZINC target
Q16236
PRO
Q16236
GlyGen
Q16236
PDB
7K2A
,
3ZGC
,
7O7B
,
7K2D
,
7K2B
,
2LZ1
,
7X5F
,
8EJR
,
8EJS
,
6T7V
,
2FLU
,
7K28
,
7X5E
,
7K2E
,
7K2C
,
7X5G
,
7K2K
,
5WFV
,
4IFL
,
7K29
HPA
ENSG00000116044-NFE2L2
Pharos - Targets
Q16236
ZINC - Predictions - Purchasable
NF2L2_HUMAN
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.978
39
UniProt:O15525 MAFG
1
MAFG [nucleoplasm]
(R-HSA-1008212)
0.939
16
UniProt:O60675 MAFK
1
MAFK [nucleoplasm]
(R-HSA-1008242)
0.806
7
UniProt:Q9ULX9 MAFF
1
MAFF [nucleoplasm]
(R-HSA-1008261)
0.77
6
UniProt:P18848 ATF4
2
ATF4 [cytosol]
(R-HSA-381084)
ATF4 [nucleoplasm]
(R-HSA-381016)
0.727
8
IntAct:EBI-4399559 UBIQ
0.667
3
UniProt:P13805 TNNT1
1
TNNT1 [cytosol]
(R-HSA-390544)
0.666
4
UniProt:O60519 CRBL2
0.625
5
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.625
5
UniProt:O15144 ARPC2
1
ARPC2 [cytosol]
(R-HSA-200809)
0.625
5
UniProt:P43268 ETV4
1
ETV4 [nucleoplasm]
(R-HSA-5687030)
0.625
6
UniProt:P20226 TBP
1
TBP [nucleoplasm]
(R-HSA-83718)
0.625
5
UniProt:Q10587 TEF
0.625
5
UniProt:P41212 ETV6
14
ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703308)
ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703302)
ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703305)
ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol]
(R-HSA-9703318)
ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol]
(R-HSA-9703313)
ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol]
(R-HSA-9703312)
ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol]
(R-HSA-9703320)
ETV6(1-384)-FLT3(573-993) fusion [cytosol]
(R-HSA-9703307)
ETV6(1-301)-FLT3(574-993) fusion [cytosol]
(R-HSA-9703315)
ETV6(1-384)-FLT3(569-993) fusion [cytosol]
(R-HSA-9697944)
ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673898)
ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673893)
p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673905)
p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673912)
0.625
5
UniProt:O75822 EIF3J
1
EIF3J [cytosol]
(R-HSA-72534)
0.625
5
UniProt:Q9NS37 ZHANG
0.625
5
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.625
5
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.625
5
UniProt:P53567 CEBPG
1
CEBPG [nucleoplasm]
(R-HSA-9644320)
0.625
5
UniProt:P15408 FOSL2
0.625
6
UniProt:P53539 FOSB
1
FOSB [nucleoplasm]
(R-HSA-9009922)
0.625
6
UniProt:P52564 MAP2K6
3
MAP2K6 [cytosol]
(R-HSA-167998)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
0.625
5
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.625
5
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.625
5
UniProt:P41227 NAA10
0.602
4
UniProt:Q13342 SP140
0.581
4
UniProt:O94916 NFAT5
0.581
4
UniProt:P50549 ETV1
0.581
4
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.581
4
UniProt:P78545 ELF3
2
ELF3 [nucleoplasm]
(R-HSA-9021353)
p-S68-ELF3 [nucleoplasm]
(R-HSA-9021349)
0.581
5
UniProt:Q9BTA9 WAC
1
WAC [nucleoplasm]
(R-HSA-8942150)
0.556
3
UniProt:P13805-3 TNNT1
0.556
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.556
5
UniProt:P0DTC5 M
10
M [plasma membrane]
(R-COV-9755780)
N-glycan M [virion membrane]
(R-COV-9694385)
M [virion membrane]
(R-COV-9694320)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum membrane]
(R-COV-9767620)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
0.547
2
UniProt:P11416 Rara
3
Rara [nucleoplasm]
(R-MMU-5618000)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-MMU-4341042)
phospho-SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-MMU-5334830)
0.544
2
UniProt:Q60953
4
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-MMU-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-MMU-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-MMU-3000440)
PML [nucleoplasm]
(R-MMU-1031706)
0.544
2
UniProt:P10276 RARA
3
RARA [nucleoplasm]
(R-HSA-446164)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
0.524
2
UniProt:P15036 ETS2
2
ETS2 [nucleoplasm]
(R-HSA-1629811)
p-T72-ETS2 [nucleoplasm]
(R-HSA-3132735)
0.508
2
UniProt:Q9UJU2 LEF1
2
pT155,S166-LEF1 [nucleoplasm]
(R-HSA-4411389)
LEF1 [nucleoplasm]
(R-HSA-3214972)
0.508
3
UniProt:Q9ULD4 BRPF3
3
BRPF3 [extracellular region]
(R-HSA-350700)
BRPF3 [cytosol]
(R-HSA-350716)
BRPF3 [nucleoplasm]
(R-HSA-3318471)
0.508
3
UniProt:Q96G23 CERS2
1
CERS2 [endoplasmic reticulum membrane]
(R-HSA-428171)
0.508
2
UniProt:P27695 APEX1
1
APEX1 [nucleoplasm]
(R-HSA-50119)
0.508
3
UniProt:P55210 CASP7
5
CASP7(24-198) [nucleoplasm]
(R-HSA-351927)
CASP7(207-303) [nucleoplasm]
(R-HSA-351924)
CASP7(2-303) [cytosol]
(R-HSA-57029)
CASP7(24-198) [cytosol]
(R-HSA-141641)
CASP7(207-303) [cytosol]
(R-HSA-141642)
0.508
2
UniProt:P15976 GATA1
1
GATA1 [nucleoplasm]
(R-HSA-996772)
0.508
2
UniProt:O75478 TADA2A
1
TADA2A [nucleoplasm]
(R-HSA-3662284)
0.508
2
UniProt:P19419 ELK1
2
ELK1 [nucleoplasm]
(R-HSA-3009346)
p-4S,T336-ELK1 [nucleoplasm]
(R-HSA-3009350)
0.508
5
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.508
2
UniProt:Q6V702 CF299
0.508
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.508
2
UniProt:P10914 IRF1
2
IRF1 [nucleoplasm]
(R-HSA-983456)
IRF1 [cytosol]
(R-HSA-1015686)
0.508
3
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.508
4
UniProt:Q77UU1 Q77UU1
0.488
2
UniProt:O95718-3 ESRRB
0.463
2
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