Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EAF1 [nucleoplasm]
Stable Identifier
R-HSA-8932787
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
ELL-associated factor 1, EAF1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P32780 GTF2H1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
EAF1 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
EAF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96JC9 EAF1
Gene Names
EAF1
Chain
chain:1-268
Reference Genes
BioGPS Gene:85403 EAF1
COSMIC (genes):EAF1 EAF1
CTD Gene:85403 EAF1
dbSNP Gene:85403 EAF1
ENSEMBL:ENSG00000144597 EAF1
HGNC:20907 EAF1
KEGG:hsa:85403 EAF1
Monarch:85403 EAF1
NCBI Gene:85403 EAF1
OMIM:608315 EAF1
UCSC:Q96JC9 EAF1
Reference Transcript
RefSeq:XM_011534166.1 EAF1
RefSeq:XM_005265518.1 EAF1
RefSeq:NM_033083.6 EAF1
RefSeq:XM_011534165.1 EAF1
Other Identifiers
11724306_at
11748059_a_at
11758126_s_at
16938102
226952_PM_at
226952_at
2612373
2612374
2612375
2612376
2612378
2612381
2612383
2612384
2612385
2612386
2612387
2612388
53670_at
75439_at
8078138
85403
A_23_P166742
A_24_P174461
A_24_P941930
GE63368
GE83603
GO:0003711
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0006368
GO:0008023
GO:0015030
GO:0016604
GO:0016607
GO:0032783
GO:0034243
GO:0043226
GO:0043231
GO:0045171
GO:0140110
HMNXSV003025903
Hs.63131.0.A1_3p_at
ILMN_1685012
PH_hs_0026451
TC03000096.hg
Participates
as an output of
Elongating transcript encounters a lesion in the template (Homo sapiens)
as a component of
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
as an input of
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Inferred To
EAF1 [nucleoplasm]
(Bos taurus)
EAF1 [nucleoplasm]
(Canis familiaris)
EAF1 [nucleoplasm]
(Gallus gallus)
EAF1 [nucleoplasm]
(Sus scrofa)
eaf1 [nucleoplasm]
(Schizosaccharomyces pombe)
eaf1 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of EAF1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of EAF1 [nucleoplasm]
(Saccharomyces cerevisiae)
eaf-1 [nucleoplasm]
(Caenorhabditis elegans)
Eaf1 [nucleoplasm]
(Mus musculus)
Eaf1 [nucleoplasm]
(Rattus norvegicus)
Eaf [nucleoplasm]
(Drosophila melanogaster)
Cross References
OpenTargets
ENSG00000144597
ENSEMBL
ENSP00000380054
,
ENST00000396842
HPA
ENSG00000144597-EAF1
PRO
Q96JC9
Pharos - Targets
Q96JC9
GlyGen
Q96JC9
PDB
7OKY
,
7OKX
Interactors (69)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.841
9
UniProt:O00472 ELL2
1
ELL2 [nucleoplasm]
(R-HSA-6807506)
0.8
9
UniProt:Q9HB65 ELL3
1
ELL3 [nucleoplasm]
(R-HSA-6807497)
0.8
8
UniProt:Q9NSC5 HOMER3
1
HOMER3 [cytosol]
(R-HSA-6794236)
0.781
7
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.675
4
UniProt:P55199 ELL
1
ELL [nucleoplasm]
(R-HSA-54257)
0.643
5
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.643
5
UniProt:P51825 AFF1
0.643
5
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.643
6
UniProt:Q9Y2F5 ICE1
1
ICE1 [nucleoplasm]
(R-HSA-6807433)
0.643
6
UniProt:Q659A1 ICE2
1
ICE2 [nucleoplasm]
(R-HSA-6807421)
0.643
6
UniProt:Q8NCX0-3 CCDC150
0.556
3
UniProt:Q96MF2 STAC3
0.556
5
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.556
3
UniProt:Q5SQQ9-2 VAX1
0.556
3
UniProt:Q15560 TCEA2
0.556
3
UniProt:P19237 TNNI1
1
TNNI1 [cytosol]
(R-HSA-390539)
0.556
3
UniProt:Q9NWS0 PIHD1
0.556
3
UniProt:P37108 SRP14
4
SRP14 [cytosol]
(R-HSA-264941)
SRP14 [ficolin-1-rich granule lumen]
(R-HSA-6800439)
SRP14 [extracellular region]
(R-HSA-6806495)
SRP14 [secretory granule lumen]
(R-HSA-6800938)
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:Q12800 TFCP2
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.556
3
UniProt:P32780 GTF2H1
1
GTF2H1 [nucleoplasm]
(R-HSA-65912)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.556
5
UniProt:Q7L190 DPPA4
1
DPPA4 [nucleoplasm]
(R-HSA-452999)
0.556
3
UniProt:Q92759 GTF2H4
1
GTF2H4 [nucleoplasm]
(R-HSA-65918)
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:P04279-2 SEMG1
0.556
3
UniProt:Q9H147 TDIF1
0.556
3
UniProt:Q8IY57-5 YAF2
0.556
5
UniProt:Q8N8X9 MB213
0.556
3
UniProt:Q8TE85-2 GRHL3
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:Q86W67 F228A
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:O95125 ZNF202
1
ZNF202 [nucleoplasm]
(R-HSA-975010)
0.556
3
UniProt:Q4LE39-3 ARID4B
0.556
3
UniProt:Q5JQS6 GSAML
0.556
3
IntAct:EBI-23645769 CCSB ORF ID
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q86T90 K1328
0.556
3
UniProt:Q8N7W2-2 BEND7
0.556
3
UniProt:Q6ZNG0 ZNF620
1
ZNF620 [nucleoplasm]
(R-HSA-2127603)
0.556
3
UniProt:O95379 TNFAIP8
1
TNFAIP8 [cytosol]
(R-HSA-8874463)
0.556
3
UniProt:O43829 ZBT14
0.556
3
UniProt:P52747 ZNF143
1
ZNF143 [nucleoplasm]
(R-HSA-83837)
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:O75052 CAPON
0.527
2
UniProt:Q8TBX8 PIP4K2C
2
PIP4K2C [cytosol]
(R-HSA-1604638)
PIP4K2C [nucleoplasm]
(R-HSA-6811499)
0.527
3
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.527
2
UniProt:Q5VWQ0 RSBN1
0.527
3
UniProt:Q8N9U0 TAC2N
0.527
3
UniProt:P78356 PIP4K2B
3
p-S326-PIP4K2B [nucleoplasm]
(R-HSA-8877679)
PIP4K2B [nucleoplasm]
(R-HSA-6811503)
PIP4K2B [cytosol]
(R-HSA-1806208)
0.527
3
UniProt:Q8N3E9 PLCD3
1
PLCD3 [plasma membrane]
(R-HSA-2023882)
0.527
3
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.527
2
UniProt:P48426 PIP4K2A
2
PIP4K2A [cytosol]
(R-HSA-1604641)
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
0.527
2
UniProt:Q9H5J8 TAF1D
1
TAF1D [nucleoplasm]
(R-HSA-5138533)
0.527
2
UniProt:Q9Y6J0 CABIN1
1
CABIN1 [nucleoplasm]
(R-HSA-3878125)
0.527
3
UniProt:Q9BQ90 KLHDC3
1
KLHDC3 [cytosol]
(R-HSA-535552)
0.527
3
UniProt:Q03111 MLLT1
1
MLLT1 [nucleoplasm]
(R-HSA-8932918)
0.527
4
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.499
5
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text