Reactome | EAF2 [nucleoplasm]

EAF2 [nucleoplasm]

Stable Identifier

R-HSA-8932790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ELL-associated factor 2, EAF2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15560

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External Reference Information

External Reference

UniProt:Q96CJ1 EAF2

Gene Names

EAF2, TRAITS, BM-040

Chain

chain:1-260

Reference Genes

BioGPS Gene:55840 EAF2

COSMIC (genes):EAF2 EAF2

CTD Gene:55840 EAF2

dbSNP Gene:55840 EAF2

ENSEMBL:ENSG00000145088 EAF2

HGNC:23115 EAF2

KEGG Gene (Homo sapiens):55840 EAF2

Monarch:55840 EAF2

NCBI Gene:55840 EAF2

OMIM:607659 EAF2

UCSC:Q96CJ1 EAF2

Reference Transcript

Other Identifiers

0005860692

11751698_a_at

16944574

219551_at

2638688

2638689

2638698

2638704

2638706

2638708

2638714

2638715

2638716

43990_at

55840

8082003

A_14_P119916

A_23_P252201

GE61955

GO:0003674

GO:0003711

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006355

GO:0006366

GO:0006368

GO:0006915

GO:0008023

GO:0008150

GO:0008219

GO:0009058

GO:0016607

GO:0032783

GO:0032991

GO:0034243

GO:0034641

GO:0043226

GO:0045944

HMNXSV003016612

ILMN_1708798

PH_hs_0018693

TC03000624.hg

g8922098_3p_at

Participates

as an output of

Elongating transcript encounters a lesion in the template (Homo sapiens)

as a component of

as an input of

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)

Inferred To

eaf2 [nucleoplasm] (Danio rerio)

eaf1 [nucleoplasm] (Schizosaccharomyces pombe)

Eaf2 [nucleoplasm] (Mus musculus)

Eaf2 [nucleoplasm] (Rattus norvegicus)

eaf-1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of EAF2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of EAF2 [nucleoplasm] (Gallus gallus)

Ghost homologue of EAF2 [nucleoplasm] (Saccharomyces cerevisiae)

EAF2 [nucleoplasm] (Bos taurus)

EAF2 [nucleoplasm] (Canis familiaris)

EAF2 [nucleoplasm] (Sus scrofa)

Eaf [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001306970.1, XP_016862351.1, XP_016862350.1, NP_060926.2

OpenTargets

ENSG00000145088

GeneCards

Q96CJ1

HPA

ENSG00000145088-EAF2

Ensembl

ENSG00000145088, ENST00000273668, ENSP00000273668

PRO

Q96CJ1

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N7W2-2 BEND7			0.696	5
UniProt:P61289 PSME3	2	PSME3 [cytosol] (R-HSA-68816) PSME3 [nucleoplasm] (R-HSA-174310)	0.621	3
UniProt:Q13490 BIRC2	5	BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.527	2
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.524	3
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.508	4
UniProt:Q96MF2 STAC3			0.488	2
UniProt:Q7Z6G3-2 NECAB2			0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q8N448 LNX2			0.488	2
UniProt:Q8ND90 PNMA1			0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.488	2

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